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    Cytomegalovirus antibody and vascular pathology in renal transplant recipients

    246940.pdf (175.6Kb)
    Access Status
    Open access
    Authors
    Price, Patricia
    Lee, Silvia
    Affandi, Jacquita
    Parsons, Richard
    Naylor, L.
    Watts, G.
    Irish, A.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Price, P. and Lee, S. and Affandi, J. and Parsons, R. and Naylor, L. and Watts, G. and Irish, A. 2017. Cytomegalovirus antibody and vascular pathology in renal transplant recipients. Journal of Medical Virology. 89 (1): pp. 177-181.
    Source Title
    Journal of Medical Virology
    DOI
    10.1002/jmv.24602
    ISSN
    0146-6615
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/37480
    Collection
    • Curtin Research Publications
    Abstract

    Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease.

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