Cytomegalovirus antibody and vascular pathology in renal transplant recipients
MetadataShow full item record
Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease.
Showing items related by title, author, creator and subject.
Cytomegalovirus viraemia and mortality in renal transplant recipients in the era of antiviral prophylaxis. Lessons from the western Australian experienceSelvey, Linda; Lim, W.; Boan, P.; Swaminathan, R.; Slimings, C.; Harrison, Amy; Chakera, A. (2017)Background: Cytomegalovirus (CMV) establishes a lifelong infection that is efficiently controlled by the immune system; this infection can be reactivated in case of immunosuppression such as following solid organ ...
Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantationCohrs, C.; Chen, C.; Jahn, S.; Stertmann, J.; Chmelova, H.; Weitz, J.; Bähr, A.; Klymiuk, N.; Steffen, A.; Ludwig, B.; Kamvissi, V.; Wolf, E.; Bornstein, S.; Solimena, Michele; Speier, S. (2017)Copyright © 2017 Endocrine Society. Islet-cell hormone release is modulated by signals from endothelial and endocrine cells within the islet. However, models of intraislet vascularization and paracrine cell signaling are ...
The effect of genetic variants affecting NK cell function on cardiovascular health and the burden of CMVWaters, Shelley; Lee, Silvia; Affandi, Jacquita; Irish, A.; Price, Patricia (2017)Renal transplant recipients (RTR) display high burdens of cytomegalovirus (CMV) and accelerated cardiovascular change. NK cells can control CMV and may contribute to vascular pathologies. Polymorphisms in genes encoding ...