Cytomegalovirus antibody and vascular pathology in renal transplant recipients
Embargo Lift Date
MetadataShow full item record
Cytomegalovirus (CMV) has been linked with vascular pathology and is a common complication of renal transplantation. We addressed whether CMV seropositivity influences vascular pathology several years after transplant. Levels of CMV antibody increased with age, were higher in transplant recipients than healthy controls (P < 0.001), and correlated with vascular endothelial function measured by flow mediated-dilation of the brachial artery (FMD). However, the optimal general linear model predicting FMD included CMV seropositivity as a marginal effect (P = 0.068), with age (P = 0.013), gender (P < 0.0001), and transplantation (P < 0.0001). Other measures of the burden of CMV are being tested as CMV prophylaxis is feasible as an approach to reduce vascular disease.
Showing items related by title, author, creator and subject.
Response of non-vascular epiphytes to simulated climate change in a montane moist evergreen broad-leaved forest in southwest ChinaSong, L.; Liu, Wen-Yao; Nadkarni, N. (2012)Interest in the potential effects of global climate change on forest ecosystems is increasing, but little is known about their effects on canopy communities, even though their reliance on atmospheric moisture and nutrients ...
Cheung, K.; Ma, L.; Wang, G.; Coe, D.; Ferro, R.; Falasca, Marco; Buckley, C.; Mauro, C.; Marelli-Berg, F. (2015)Maintenance of vascular integrity during effector immune responses occurring in tissues is a prerequisite of a healthy immune response. The mechanism whereby the vascular endothelium remains undamaged while interacting ...
Jin, X.; Zeng, L.; Zhang, S.; He, S.; Ren, Y.; Chen, Younan; Wei, L.; Wang, L.; Li, H.; Cheng, J.; Lu, Y. (2013)Monkeys with insulin-dependent diabetes are important preclinical animal models for islet transplantation. Exogenous insulin should be administered to achieve good glycemic control and minimize the long-term vascular ...