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    Molecular imaging of plaques in coronary arteries with PET and SPECT

    200801_132779_20140813001.pdf (1.683Mb)
    Access Status
    Open access
    Authors
    Sun, Zhonghua
    Rashmizal, H.
    Xu, L.
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Sun, Z. and Rashmizal, H. and Xu, L. 2014. Molecular imaging of plaques in coronary arteries with PET and SPECT. Journal of Geriatric Cardiology. 11 (3): pp. 259-273.
    Source Title
    Journal of Geriatric Cardiology
    DOI
    10.11909/j.issn.1671-5411.2014.03.005
    ISSN
    1671-5411
    School
    Department of Imaging and Applied Physics
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons License http://creativecommons.org/licenses/by/2.5/ Please refer to the licence to obtain terms for any further reuse or distribution of this work

    URI
    http://hdl.handle.net/20.500.11937/37715
    Collection
    • Curtin Research Publications
    Abstract

    Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lumen stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increasingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of PET and SPECT has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging techniques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coronary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed.

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