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dc.contributor.authorSun, Zhonghua
dc.contributor.authorRashmizal, H.
dc.contributor.authorXu, L.
dc.identifier.citationSun, Z. and Rashmizal, H. and Xu, L. 2014. Molecular imaging of plaques in coronary arteries with PET and SPECT. Journal of Geriatric Cardiology. 11 (3): pp. 259-273.

Coronary artery disease remains a major cause of mortality. Presence of atherosclerotic plaques in the coronary artery is responsible for lumen stenosis which is often used as an indicator for determining the severity of coronary artery disease. However, the degree of coronary lumen stenosis is not often related to compromising myocardial blood flow, as most of the cardiac events that are caused by atherosclerotic plaques are the result of vulnerable plaques which are prone to rupture. Thus, identification of vulnerable plaques in coronary arteries has become increasingly important to assist identify patients with high cardiovascular risks. Molecular imaging with use of PET and SPECT has fulfilled this goal by providing functional information about plaque activity which enables accurate assessment of plaque stability. This review article provides an overview of diagnostic applications of molecular imaging techniques in the detection of plaques in coronary arteries with PET and SPECT. New radiopharmaceuticals used in the molecular imaging of coronary plaques and diagnostic applications of integrated PET/CT and PET/MRI in coronary plaques are also discussed.

dc.publisherChinese P L A General Hospital * Institute of Geriatric Cardiology
dc.subjectsingle photon emission computed tomography
dc.subjectcoronary artery disease
dc.subjectpositron emission tomography
dc.subjectatherosclerotic plaque
dc.titleMolecular imaging of plaques in coronary arteries with PET and SPECT
dc.typeJournal Article
dcterms.source.titleJournal of Geriatric Cardiology

This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons License Please refer to the licence to obtain terms for any further reuse or distribution of this work

curtin.departmentDepartment of Imaging and Applied Physics
curtin.accessStatusOpen access

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