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dc.contributor.authorReid, L.
dc.contributor.authorBoyd, Roslyn
dc.contributor.authorCunnington, R.
dc.contributor.authorRose, S.
dc.date.accessioned2017-01-30T14:10:51Z
dc.date.available2017-01-30T14:10:51Z
dc.date.created2016-02-16T19:30:23Z
dc.date.issued2016
dc.identifier.citationReid, L. and Boyd, R. and Cunnington, R. and Rose, S. 2016. Interpreting intervention induced neuroplasticity with fMRI: The case for multimodal imaging strategies. Neural Plasticity. 2016 (Article ID 2643491): pp. 1-13.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/38016
dc.identifier.doi10.1155/2016/2643491
dc.description.abstract

© 2016 Lee B. Reid et al. Direct measurement of recovery from brain injury is an important goal in neurorehabilitation, and requires reliable, objective, and interpretable measures of changes in brain function, referred to generally as "neuroplasticity." One popular imaging modality for measuring neuroplasticity is task-based functional magnetic resonance imaging (t-fMRI). In the field of neurorehabilitation, however, assessing neuroplasticity using t-fMRI presents a significant challenge. This commentary reviews t-fMRI changes commonly reported in patients with cerebral palsy or acquired brain injuries, with a focus on studies of motor rehabilitation, and discusses complexities surrounding their interpretations. Specifically, we discuss the difficulties in interpreting t-fMRI changes in terms of their underlying causes, that is, differentiating whether they reflect genuine reorganisation, neurological restoration, compensation, use of preexisting redundancies, changes in strategy, or maladaptive processes. Furthermore, we discuss the impact of heterogeneous disease states and essential t-fMRI processing steps on the interpretability of activation patterns. To better understand therapy-induced neuroplastic changes, we suggest that researchers utilising t-fMRI consider concurrently acquiring information from an additional modality, to quantify, for example, haemodynamic differences or microstructural changes. We outline a variety of such supplementary measures for investigating brain reorganisation and discuss situations in which they may prove beneficial to the interpretation of t-fMRI data.

dc.titleInterpreting intervention induced neuroplasticity with fMRI: The case for multimodal imaging strategies
dc.typeJournal Article
dcterms.source.volume2016
dcterms.source.issn2090-5904
dcterms.source.titleNeural Plasticity
curtin.departmentSchool of Occupational Therapy and Social Work
curtin.accessStatusOpen access via publisher


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