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    Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin

    Access Status
    Open access via publisher
    Authors
    Manchun, S.
    Dass, Crispin
    Sriamornsak, P.
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Manchun, S. and Dass, C. and Sriamornsak, P. 2016. Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin. Asian Journal of Pharmaceutical Sciences. 11 (5): pp. 648-654.
    Source Title
    Asian Journal of Pharmaceutical Sciences
    DOI
    10.1016/j.ajps.2015.09.006
    ISSN
    1818-0876
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/38338
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 The Authors. Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated (25?°C/60% RH) and long-term (5?°C) stability of DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared (initial day) and after storage at 5?°C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different (p?>?0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5?°C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5?°C.

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