Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin
dc.contributor.author | Manchun, S. | |
dc.contributor.author | Dass, Crispin | |
dc.contributor.author | Sriamornsak, P. | |
dc.date.accessioned | 2017-01-30T14:16:52Z | |
dc.date.available | 2017-01-30T14:16:52Z | |
dc.date.created | 2016-09-15T06:04:38Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Manchun, S. and Dass, C. and Sriamornsak, P. 2016. Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin. Asian Journal of Pharmaceutical Sciences. 11 (5): pp. 648-654. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/38338 | |
dc.identifier.doi | 10.1016/j.ajps.2015.09.006 | |
dc.description.abstract |
© 2016 The Authors. Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated (25?°C/60% RH) and long-term (5?°C) stability of DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared (initial day) and after storage at 5?°C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different (p?>?0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5?°C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5?°C. | |
dc.title | Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin | |
dc.type | Journal Article | |
dcterms.source.volume | 11 | |
dcterms.source.number | 5 | |
dcterms.source.startPage | 648 | |
dcterms.source.endPage | 654 | |
dcterms.source.issn | 1818-0876 | |
dcterms.source.title | Asian Journal of Pharmaceutical Sciences | |
curtin.department | School of Pharmacy | |
curtin.accessStatus | Open access via publisher |
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