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    Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate golgi functionality

    Access Status
    Fulltext not available
    Authors
    Mousley, Carl
    Davison, J.
    Bankaitis, V.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Mousley, C. and Davison, J. and Bankaitis, V. 2015. Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate golgi functionality. Sub-Cellular Biochemistry. 59: pp. 271-287.
    Source Title
    Sub-Cellular Biochemistry
    DOI
    10.1007/978-94-007-3015-1_9
    ISSN
    0306-0225
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/38424
    Collection
    • Curtin Research Publications
    Abstract

    An interface coordinating lipid metabolism with proteins that regulate membrane trafficking is necessary to regulate Golgi morphology and dynamics. Such an interface facilitates the membrane deformations required for vesicularization, forms platforms for protein recruitment and assembly on appropriate sites on a membrane surface and provides lipid co-factors for optimal protein activity in the proper spatio-temporally regulated manner. Importantly, Sec14 and Sec14-like proteins are a unique superfamily of proteins that sense specific aspects of lipid metabolism, employing this information to potentiate phosphoinositide production. Therefore, Sec14 and Sec14 like proteins form central conduits to integrate multiple aspects of lipid metabolism with productive phosphoinositide signaling.

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