The effect of a single nucleotide polymorphismof the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acidexcretion after weight loss
dc.contributor.author | Ward, Natalie | |
dc.contributor.author | Croft, K. | |
dc.contributor.author | Puddey, I. | |
dc.contributor.author | Phillips, M. | |
dc.contributor.author | van Bockxmeer, F. | |
dc.contributor.author | Beilin, L. | |
dc.contributor.author | Barden, A. | |
dc.date.accessioned | 2017-01-30T14:22:02Z | |
dc.date.available | 2017-01-30T14:22:02Z | |
dc.date.created | 2016-01-19T20:00:32Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Ward, N. and Croft, K. and Puddey, I. and Phillips, M. and van Bockxmeer, F. and Beilin, L. and Barden, A. 2014. The effect of a single nucleotide polymorphismof the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acidexcretion after weight loss. Journal of Hypertension. 32 (7): pp. 1495-1502. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/38490 | |
dc.identifier.doi | 10.1097/HJH.0000000000000208 | |
dc.description.abstract |
Background: Genetic background partly determines the efficacy of interventions to lower blood pressure (BP). The CYP4F2 and CYP4A11 enzymes are renal 20-hydroxyeicosatetraenoic acid (20-HETE) synthases that regulate BP. Gene variants of CYP4F2 and CYP4A11 associate with hypertension and stroke. We showed that a gene variant of CYP4F2 but not CYP4A11 was associated with increased 20-HETE excretion and BP. Aim: To compare BP and 20-HETE responses in carriers of the CYP4F2 1347G/A polymorphism and controls CYP4F2-GG (wildtype), during weight loss. Methods: Volunteers genotyped as CYP4F2GA/AA (n = 26) and controls genotyped as CYP4F2 GG (n = 27) were counselled to reduce weight for 12 weeks, followed by 4 weeks of weight stabilization. Weight, 24-h BP, pulse pressure and urinary 20-HETE were measured at baseline, 12 and 16 weeks. Results: At baseline, SBP was (+1.7 mmHg, P = 0.047) in the CYP4F2 GA/AA genotype. Compared with baseline, weight fell by 3.9 kg, P = 0.0001, in both genotypes, and was maintained to 16 weeks. SBP fell by (−7.6 mmHg, P = 0.004) in both genotypes after 12 weeks. However, after weight stabilization, SBP was +3.6 mmHg, P = 0.004 in CYP4F2 GA/AA genotype. DBP and heart rate changed similarly over time. Pulse pressure fell with weight loss (P < 0.001), but was elevated in the CYP4F2 GA/AA genotype at all time-points (+3.1 mmHg, P < 0.001). Urinary 20-HETE was similar at baseline and 12 weeks but elevated in the CYP4F2 GA/AA genotype (P = 0.017) after weight stabilization. Conclusion: Maintenance of lower BP after weight loss is more difficult for carriers of the CYP4F2 G1347A polymorphism and may be related to increased arterial stiffness and increased 20-HETE synthesis. | |
dc.title | The effect of a single nucleotide polymorphismof the CYP4F2 gene on blood pressure and 20-hydroxyeicosatetraenoic acidexcretion after weight loss | |
dc.type | Journal Article | |
dcterms.source.volume | 32 | |
dcterms.source.number | 7 | |
dcterms.source.startPage | 1495 | |
dcterms.source.endPage | 1502 | |
dcterms.source.issn | 0263-6352 | |
dcterms.source.title | Journal of Hypertension | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Fulltext not available |
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