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dc.contributor.authorGoodwin, Stephen B.
dc.contributor.authorM’Barek, Sarrah Ben
dc.contributor.authorDhillon, Braham
dc.contributor.authorWittenberg, Alexander H. J.
dc.contributor.authorCrane, Charles F.
dc.contributor.authorHane, James K.
dc.contributor.authorFoster, Andrew J.
dc.contributor.authorVan der Lee, Theo A. J.
dc.contributor.authorGrimwood, Jane
dc.contributor.authorAerts, Andrea
dc.contributor.authorAntoniw, John
dc.contributor.authorBailey, Andy
dc.contributor.authorBluhm, Burt
dc.contributor.authorBowler, Judith
dc.contributor.authorBristow, Jim
dc.contributor.authorvan der Burgt, Ate
dc.contributor.authorCanto-Canche, Blondy
dc.contributor.authorChurchill, Alice C. L.
dc.contributor.authorConde-Ferraez, Laura
dc.contributor.authorCools, Hans J.
dc.contributor.authorCoutinho, Pedro M.
dc.contributor.authorCsukai, Michael
dc.contributor.authorDehal, Paramvir
dc.contributor.authorDe Wit, Pierre
dc.contributor.authorDonzelli, Bruno
dc.contributor.authorvan de Geest, Henri C.
dc.contributor.authorvan Ham, Roel C. H. J.
dc.contributor.authorHammond-Kosack, Kim E.
dc.contributor.authorHenrissat, Bernard
dc.contributor.authorKilian, Andrzej
dc.contributor.authorKobayashi, Adilson K.
dc.contributor.authorKoopmann, Edda
dc.contributor.authorKourmpetis, Yiannis
dc.contributor.authorKuzniar, Arnold
dc.contributor.authorLindquist, Erika
dc.contributor.authorLombard, Vincent
dc.contributor.authorMaliepaard, Chris
dc.contributor.authorMartins, Natalia
dc.contributor.authorMehrabi, Rahim
dc.contributor.authorNap, Jan P. H.
dc.contributor.authorPonomarenko, Alisa
dc.contributor.authorRudd, Jason J.
dc.contributor.authorSalamov, Asaf
dc.contributor.authorSchmutz, Jeremy
dc.contributor.authorSchouten, Henk J.
dc.contributor.authorShapiro, Harris
dc.contributor.authorStergiopoulos, Ioannis
dc.contributor.authorTorriani, Stefano F.F.
dc.contributor.authorTu, Hank
dc.contributor.authorde Vries, Ronald P.
dc.contributor.authorWaalwijk, Cees
dc.contributor.authorWare, Sarah B.
dc.contributor.authorWiebenga, Ad
dc.contributor.authorZwiers, Lute-Harm
dc.contributor.authorOliver, Richard P.
dc.contributor.authorGrigoriev, Igor V.
dc.contributor.authorKema, Gert. H. J.
dc.identifier.citationGoodwin, Stephen B. and M’Barek, Sarrah Ben and Dhillon, Braham and Wittenberg, Alexander H. J. and Crane, Charles F. and Hane, James K. and Foster, Andrew J. et al. 2011. Finished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth Pathogenesis. PLos Genetics. 7 (6): pp. 1-17.

The plant-pathogenic fungus Mycosphaerella graminicola (asexual stage: Septoria tritici) causes septoria tritici blotch, a disease that greatly reduces the yield and quality of wheat. This disease is economically important in most wheat-growing areas worldwide and threatens global food production. Control of the disease has been hampered by a limited understanding of the genetic and biochemical bases of pathogenicity, including mechanisms of infection and of resistance in the host. Unlike most other plant pathogens, M. graminicola has a long latent period during which it evades host defenses. Although this type of stealth pathogenicity occurs commonly in Mycosphaerella and other Dothideomycetes, the largest class of plant-pathogenic fungi, its genetic basis is not known. To address this problem, the genome of M. graminicola was sequenced completely. The finished genome contains 21 chromosomes, eight of which could be lost with no visible effect on the fungus and thus are dispensable. This eight-chromosome dispensome is dynamic in field and progeny isolates, is different from the core genome in gene and repeat content, and appears to have originated by ancient horizontal transfer from an unknown donor. Synteny plots of the M. graminicola chromosomes versus those of the only other sequenced Dothideomycete, Stagonospora nodorum, revealed conservation of gene content but not order or orientation, suggesting a high rate of intra-chromosomal rearrangement in one or both species.This observed “mesosynteny” is very different from synteny seen between other organisms. A surprising feature of the M. graminicola genome compared to other sequenced plant pathogens was that it contained very few genes for enzymes that break down plant cell walls, which was more similar to endophytes than to pathogens. The stealth pathogenesis of M. graminicola probably involves degradation of proteins rather than carbohydrates to evade host defenses during the biotrophic stage of infection and may have evolved from endophytic ancestors.

dc.publisherPublic Library of Science
dc.titleFinished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth Pathogenesis
dc.typeJournal Article
dcterms.source.titlePLos Genetics
curtin.departmentDepartment of Environment and Agriculture
curtin.accessStatusOpen access

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