Genome-wide analysis in three Fusarium pathogens identifies rapidly evolving chromosomes and genes associated with pathogenicity
MetadataShow full item record
Pathogens and hosts are in an ongoing arms race and genes involved in host-pathogen interactions are likely to undergo diversifying selection. Fusarium plant pathogens have evolved diverse infection strategies, but how they interact with their hosts in the biotrophic infection stage remains puzzling. To address this, we analyzed the genomes of three Fusarium plant pathogens for genes that are under diversifying selection. We found a two-speed genome structure both on the chromosome and gene group level. Diversifying selection acts strongly on the dispensable chromosomes in Fusarium oxysporum f. sp. lycopersici and on distinct core chromosome regions in Fusarium graminearum, all of which have associations with virulence. Members of two gene groups evolve rapidly, namely those that encode proteins with an N-terminal [SG]-P-C-[KR]-P sequence motif and proteins that are conserved predominantly in pathogens. Specifically, 29 F. graminearum genes are rapidly evolving, in plant a induced and encode secreted proteins, strongly pointing toward effector function. In summary, diversifying selection in Fusarium is strongly reflected as genomic footprints and can be used to predict a small gene set likely to be involved in host-pathogen interactions for experimental verification.
Showing items related by title, author, creator and subject.
Comparative Pathogenomics Reveals Horizontally Acquired Novel Virulence Genes in Fungi Infecting Cereal HostsGardiner, D.; McDonald, M.; Covarelli, Lorenzo; Solomon, P.; Rusu, A.; Marshall, M.; Kazan, K.; Chakraborty, S.; McDonald, B.; Manners, J. (2012)Comparative analyses of pathogen genomes provide new insights into how pathogens have evolved common and divergent virulence strategies to invade related plant species. Fusarium crown and root rots are important diseases ...
Comparative genomics and prediction of conditionally dispensable sequences in legume–infecting Fusarium oxysporum formae speciales facilitates identification of candidate effectorsWilliams, A.; Sharma, M.; Thatcher, L.; Azam, S.; Hane, James; Sperschneider, J.; Kidd, B.; Anderson, J.; Ghosh, R.; Garg, G.; Lichtenzveig, J.; Kistler, H.; Shea, T.; Young, S.; Buck, S.; Kamphuis, L.; Saxena, R.; Pande, S.; Ma, L.; Varshney, R.; Singh, K. (2016)Background: Soil-borne fungi of the Fusarium oxysporum species complex cause devastating wilt disease on many crops including legumes that supply human dietary protein needs across many parts of the globe. We present and ...
Finished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth PathogenesisGoodwin, S.; M’Barek, S.; Dhillon, B.; Wittenberg, A.; Crane, C.; Hane, James; Foster, A.; Van der Lee, T.; Grimwood, J.; Aerts, A.; Antoniw, J.; Bailey, A.; Bluhm, B.; Bowler, J.; Bristow, J.; van der Burgt, A.; Canto-Canche, B.; Churchill, A.; Conde-Ferraez, L.; Cools, H.; Coutinho, P.; Csukai, M.; Dehal, P.; De Wit, P.; Donzelli, B.; van de Geest, H.; van Ham, R.; Hammond-Kosack, K.; Henrissat, B.; Kilian, A.; Kobayashi, A.; Koopmann, E.; Kourmpetis, Y.; Kuzniar, A.; Lindquist, E.; Lombard, V.; Maliepaard, C.; Martins, N.; Mehrabi, R.; Nap, J.; Ponomarenko, A.; Rudd, J.; Salamov, A.; Schmutz, J.; Schouten, H.; Shapiro, H.; Stergiopoulos, I.; Torriani, S.; Tu, H.; de Vries, R.; Waalwijk, C.; Ware, S.; Wiebenga, A.; Zwiers, L.; Oliver, Richard; Grigoriev, I.; Kema, G. (2011)The plant-pathogenic fungus Mycosphaerella graminicola (asexual stage: Septoria tritici) causes septoria tritici blotch, a disease that greatly reduces the yield and quality of wheat. This disease is economically important ...