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    Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy

    192835_192835.pdf (999.5Kb)
    Access Status
    Open access
    Authors
    Feng, Xiaohui
    Zhang, Shaokun
    Lou, Xia
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Feng, Xiaohui and Zhang, Shaokun and Lou, Xia. 2013. Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy. Colloids and Surfaces B: Biointerfaces. 107: pp. 220-226.
    Source Title
    Colloids and Surfaces B: Biointerfaces
    DOI
    10.1016/j.colsurfb.2013.02.007
    ISSN
    0927-7765
    Remarks

    Copyright © 2013 Elsevier

    URI
    http://hdl.handle.net/20.500.11937/38817
    Collection
    • Curtin Research Publications
    Abstract

    Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy.In this paper, core–shell structured titanium dioxide–silica (TiO2–SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicityand photo-killing ability of the TiO2 nanoparticles was investigated. Silica coating reduced the photocatalytic reactivity but improved the cytocompatibility of the TiO2 nanoparticles. This effect was amplified with increasing silica shell thickness. When the silica thickness was about 5.5 nm, the coated TiO2 not only retained a high level photodynamic reactivity, comparable to the non-coated TiO2 nanoparticles, but also demonstrated an improved cell compatibility and effective photo-killing ability upon the mouse fibroblast cells (L929).

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