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dc.contributor.authorFeng, Xiaohui
dc.contributor.authorZhang, Shaokun
dc.contributor.authorLou, Xia
dc.identifier.citationFeng, Xiaohui and Zhang, Shaokun and Lou, Xia. 2013. Controlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy. Colloids and Surfaces B: Biointerfaces. 107: pp. 220-226.

Photosensitive nanoparticles are useful in developing phototherapeutic agents for targeted cancer therapy.In this paper, core–shell structured titanium dioxide–silica (TiO2–SiO2) nanoparticles, with varying shell thickness, were synthesized. The influence of the silica shell thickness on the photoreactivity, cytotoxicityand photo-killing ability of the TiO2 nanoparticles was investigated. Silica coating reduced the photocatalytic reactivity but improved the cytocompatibility of the TiO2 nanoparticles. This effect was amplified with increasing silica shell thickness. When the silica thickness was about 5.5 nm, the coated TiO2 not only retained a high level photodynamic reactivity, comparable to the non-coated TiO2 nanoparticles, but also demonstrated an improved cell compatibility and effective photo-killing ability upon the mouse fibroblast cells (L929).

dc.publisherElsevier BV
dc.subjectPhoto-killing agent
dc.subjectSilica coating
dc.subjectPhotodynamic therapy
dc.subjectTiO2 nanoparticles
dc.subjectSilica-coated TiO2 nanoparticles
dc.titleControlling silica coating thickness on TiO2 nanoparticles for effective photodynamic therapy
dc.typeJournal Article
dcterms.source.titleColloids and Surfaces B: Biointerfaces

Copyright © 2013 Elsevier

curtin.accessStatusOpen access

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