Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Consumption of a high-salt diet by ewes during pregnancy alters nephrogenesis in 5-month-old offspring

    187515_66059_Consumption.pdf (519.1Kb)
    Access Status
    Open access
    Authors
    Tay, S.
    Blache, D.
    Gregg, Keith
    Revell, D.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Tay, S.H. and Blache, D. and Gregg, K. and Revell, D.K. 2012. Consumption of a high-salt diet by ewes during pregnancy alters nephrogenesis in 5-month-old offspring. animal. 6 (11): pp. 1803-1810.
    Source Title
    Animal: the international journal of animal biosciences
    DOI
    10.1017/S1751731112000584
    ISSN
    1751-7311
    Remarks

    Copyright © 2012 The Animal Consortium

    URI
    http://hdl.handle.net/20.500.11937/38841
    Collection
    • Curtin Research Publications
    Abstract

    Maternal nutrition during pregnancy can affect kidney development in the foetus, which may lead to adverse consequences in the mature kidney. It was expected that high-salt intake by pregnant ewes would lead to a reduction in foetal glomerular number but that the ovine kidney would adapt to maintain homoeostasis, in part by increasing the size of each glomerulus. Merino ewes that were fed either a control (1.5% NaCl) or high-salt (10.5% NaCl) diet during pregnancy, as well as their 5-month-old offspring, were subjected to a dietary salt challenge, and glomerular number and size and sodium excretion were measured. The high-salt offspring had 20% fewer glomeruli compared with the control offspring ( P,0.001), but they also had larger glomerular radii compared with the control offspring ( P,0.001). Consequently, the cross-sectional area of glomeruli was 18% larger in the high-salt offspring than in the control offspring ( P,0.05). There was no difference in the daily urinary sodium excretion between the two offspring groups ( P.0.05), although the high-salt offspring produced urine with a higher concentration of sodium. Our results demonstrated that maternal high-salt intake during pregnancy affected foetal nephrogenesis, altering glomerular number at birth. However, the ability to concentrate and excrete salt was not compromised, which indicates that the kidney was able to adapt to the reduction in the number of glomeruli.

    Related items

    Showing items related by title, author, creator and subject.

    • Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years: observation from a birth cohort study.
      Das, S.; McIntyre, H.; Alati, Rosa; Al Mamun, A. (2017)
      AIM: Prenatal exposure to alcohol has adverse ramifications on foetal development resulting in developmental abnormalities and major congenital anomalies. Experimental studies have documented effects on kidney structure ...
    • Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice)
      Smoothy, J.; Larcombe, Alexander ; Chivers, E.K.; Matthews, V.B.; Gorman, S. (2019)
      © 2019 The Author(s). Published in Respiratory Research. Background: Epidemiological studies have identified strong relationships between maternal obesity and offspring respiratory dysfunction; however, the causal direction ...
    • Risk of Progression of Nonalbuminuric CKD to End-Stage Kidney Disease in People With Diabetes: The CRIC (Chronic Renal Insufficiency Cohort) Study
      Koye, D.; Magliano, D.; Reid, Christopher; Jepson, C.; Feldman, H.; Herman, W.; Shaw, J. (2018)
      Background: Reduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the frequency with which it progresses to end-stage kidney ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.