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    Age-related changes in short-interval intracortical facilitation and dexterity

    225595_225595.pdf (383.7Kb)
    Access Status
    Open access
    Authors
    Clark, J.
    Loftus, Andrea
    Hammond, G.
    Date
    2011
    Type
    Journal Article
    
    Metadata
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    Citation
    Clark, J. and Loftus, A. and Hammond, G. 2011. Age-related changes in short-interval intracortical facilitation and dexterity. NeuroReport. 22 (10): pp. 499-503.
    Source Title
    NeuroReport
    ISSN
    0959-4965
    Remarks

    This is a non-final version of an article published in final form in Clark, J. and Loftus, A. and Hammond, G. 2011. Age-related changes in short-interval intracortical facilitation and dexterity. NeuroReport. 22 (10): pp. 499-503.

    URI
    http://hdl.handle.net/20.500.11937/39178
    Collection
    • Curtin Research Publications
    Abstract

    Functional changes in the primary motor cortex might contribute to the age-related decline infine motor control. We measured short-interval intracortical facilitation (SICF) in an intrinsichand muscle with paired-pulse transcranial magnetic stimulation at interstimulus intervals(ISIs) of 1.5, 2.5, and 4.5 ms in young and old subjects and examined its association withdexterity. We found age-related effects in SICF, with greater facilitation in old than youngsubjects at the 1.5-ms ISI and greater facilitation in young than old subjects at the 2.5-ms ISI.SICF at the 2.5-ms ISI was positively correlated with performance on a task that requiredcoordinated and dextrous use of both hands, suggesting that this measure indicates a capacityfor executing demanding manual tasks.

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