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    Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model

    189809_74006_Paper_11.pdf (7.697Mb)
    Access Status
    Open access
    Authors
    Wong, K.
    Thavornpattanapong, P.
    Cheung, S.
    Sun, Zhonghua
    Tu, J.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Wong, Kelvin and Thavornpattanapong, Pongpat and Cheung, Sherman and Sun, Zhonghua and Tu, Jiyuan. 2012. Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model. BMC Cardiovascular Disorders. 12 (7): pp. 1-18.
    Source Title
    BMC Cardiovascular Disorders
    DOI
    10.1186/1471-2261-12-7
    ISSN
    1471-2261
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/39420
    Collection
    • Curtin Research Publications
    Abstract

    Background: This study characterizes the distribution and components of plaque structure by presenting a three-dimensional blood-vessel modelling with the aim of determining mechanical properties due to the effect of lipid core and calcification within a plaque. Numerical simulation has been used to answer how cap thickness and calcium distribution in lipids influence the biomechanical stress on the plaque. Method: Modelling atherosclerotic plaque based on structural analysis confirms the rationale for plaque mechanical examination and the feasibility of our simulation model. Meaningful validation of predictions from modelled atherosclerotic plaque model typically requires examination of bona fide atherosclerotic lesions. To analyze a more accurate plaque rupture, fluid-structure interaction is applied to three-dimensional blood-vessel carotid bifurcation modelling. A patient-specific pressure variation is applied onto the plaque to influence its vulnerability. Results: Modelling of the human atherosclerotic artery with varying degrees of lipid core elasticity, fibrous cap thickness and calcification gap, which is defined as the distance between the fibrous cap and calcification agglomerate, form the basis of our rupture analysis. Finite element analysis shows that the calcification gap should be conservatively smaller than its threshold to maintain plaque stability. The results add new mechanistic insights and methodologically sound data to investigate plaque rupture mechanics. Conclusion: Structural analysis using a three-dimensional calcified model represents a more realistic simulation of late-stage atherosclerotic plaque. We also demonstrate that increases of calcium content that is coupled with a decrease in lipid core volume can stabilize plaque structurally.

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