Show simple item record

dc.contributor.authorWong, K.
dc.contributor.authorThavornpattanapong, P.
dc.contributor.authorCheung, S.
dc.contributor.authorSun, Zhonghua
dc.contributor.authorTu, J.
dc.date.accessioned2017-01-30T14:33:31Z
dc.date.available2017-01-30T14:33:31Z
dc.date.created2013-03-07T20:00:37Z
dc.date.issued2012
dc.identifier.citationWong, Kelvin and Thavornpattanapong, Pongpat and Cheung, Sherman and Sun, Zhonghua and Tu, Jiyuan. 2012. Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model. BMC Cardiovascular Disorders. 12 (7): pp. 1-18.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/39420
dc.identifier.doi10.1186/1471-2261-12-7
dc.description.abstract

Background: This study characterizes the distribution and components of plaque structure by presenting a three-dimensional blood-vessel modelling with the aim of determining mechanical properties due to the effect of lipid core and calcification within a plaque. Numerical simulation has been used to answer how cap thickness and calcium distribution in lipids influence the biomechanical stress on the plaque. Method: Modelling atherosclerotic plaque based on structural analysis confirms the rationale for plaque mechanical examination and the feasibility of our simulation model. Meaningful validation of predictions from modelled atherosclerotic plaque model typically requires examination of bona fide atherosclerotic lesions. To analyze a more accurate plaque rupture, fluid-structure interaction is applied to three-dimensional blood-vessel carotid bifurcation modelling. A patient-specific pressure variation is applied onto the plaque to influence its vulnerability. Results: Modelling of the human atherosclerotic artery with varying degrees of lipid core elasticity, fibrous cap thickness and calcification gap, which is defined as the distance between the fibrous cap and calcification agglomerate, form the basis of our rupture analysis. Finite element analysis shows that the calcification gap should be conservatively smaller than its threshold to maintain plaque stability. The results add new mechanistic insights and methodologically sound data to investigate plaque rupture mechanics. Conclusion: Structural analysis using a three-dimensional calcified model represents a more realistic simulation of late-stage atherosclerotic plaque. We also demonstrate that increases of calcium content that is coupled with a decrease in lipid core volume can stabilize plaque structurally.

dc.publisherBiomed Central
dc.titleEffect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model
dc.typeJournal Article
dcterms.source.volume12
dcterms.source.number7
dcterms.source.startPage1
dcterms.source.endPage18
dcterms.source.issn1471-2261
dcterms.source.titleBMC Cardiovascular Disorders
curtin.note

This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

curtin.department
curtin.accessStatusOpen access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record