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    Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety

    Access Status
    Open access via publisher
    Authors
    Solah, Vicky
    Brand-Miller, J.
    Atkinson, F.
    Gahler, R.
    Kacinik, V.
    Lyon, M.
    Wood, S.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Solah, V. and Brand-Miller, J. and Atkinson, F. and Gahler, R. and Kacinik, V. and Lyon, M. and Wood, S. 2014. Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety. Appetite. 77: pp. 74-78.
    Source Title
    Appetite
    DOI
    10.1016/j.appet.2014.02.021
    ISSN
    0195-6663
    URI
    http://hdl.handle.net/20.500.11937/39486
    Collection
    • Curtin Research Publications
    Abstract

    The objective of this research was to determine the dose–response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX® (PGX®), [(a-D-glucurono-a–manno-ß-D-manno-ß-D-gluco), (a-Lgulurono-ß-D mannurono), (ß-D-gluco-ß-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX®, in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX® doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7,P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control.

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