Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety
dc.contributor.author | Solah, Vicky | |
dc.contributor.author | Brand-Miller, J. | |
dc.contributor.author | Atkinson, F. | |
dc.contributor.author | Gahler, R. | |
dc.contributor.author | Kacinik, V. | |
dc.contributor.author | Lyon, M. | |
dc.contributor.author | Wood, S. | |
dc.date.accessioned | 2017-01-30T14:34:20Z | |
dc.date.available | 2017-01-30T14:34:20Z | |
dc.date.created | 2014-05-15T20:00:18Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Solah, V. and Brand-Miller, J. and Atkinson, F. and Gahler, R. and Kacinik, V. and Lyon, M. and Wood, S. 2014. Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety. Appetite. 77: pp. 74-78. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/39486 | |
dc.identifier.doi | 10.1016/j.appet.2014.02.021 | |
dc.description.abstract |
The objective of this research was to determine the dose–response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX® (PGX®), [(a-D-glucurono-a–manno-ß-D-manno-ß-D-gluco), (a-Lgulurono-ß-D mannurono), (ß-D-gluco-ß-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX®, in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX® doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7,P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control. | |
dc.publisher | Elsevier BV | |
dc.subject | satiety | |
dc.subject | fibre | |
dc.subject | dose | |
dc.title | Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety | |
dc.type | Journal Article | |
dcterms.source.volume | 77 | |
dcterms.source.startPage | 72 | |
dcterms.source.endPage | 76 | |
dcterms.source.issn | 0195-6663 | |
dcterms.source.title | Appetite | |
curtin.department | ||
curtin.accessStatus | Open access via publisher |