Tumour-promoting activity of altered WWPI expression in breast cancer and its utility as a prognostic indicator
dc.contributor.author | Huu, N. | |
dc.contributor.author | Ryder, W. | |
dc.contributor.author | Zeps, Nikolajs | |
dc.contributor.author | Flasza, M. | |
dc.contributor.author | Chiu, M. | |
dc.contributor.author | Hanby, A. | |
dc.contributor.author | Poulsom, R. | |
dc.contributor.author | Clarke, R. | |
dc.contributor.author | Baron, M. | |
dc.date.accessioned | 2017-01-30T14:37:04Z | |
dc.date.available | 2017-01-30T14:37:04Z | |
dc.date.created | 2016-09-12T08:36:43Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Huu, N. and Ryder, W. and Zeps, N. and Flasza, M. and Chiu, M. and Hanby, A. and Poulsom, R. et al. 2008. Tumour-promoting activity of altered WWPI expression in breast cancer and its utility as a prognostic indicator. Journal of Pathology. 216 (1): pp. 93-102. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/39791 | |
dc.identifier.doi | 10.1002/path.2385 | |
dc.description.abstract |
WWP1 is a ubiquitin ligase, associated with the post-translational regulation of several tumour-promoting and tumour suppressor proteins. Here we show that WWP1 expression is up-regulated in a subset of breast tumour cell lines and primary breast tumours. We overexpressed WWP1 in MCF10A breast epithelial cells and demonstrated increased cell growth and anchorage- independent colony formation. RNAi knockdown of WWP1 expression in T47D and MCF7 breast tumour cell lines reduced anchorage-independent colony formation. We used WWP1 protein expression levels, in combination with its subcellular localization, to classify breast tumours into four categories. Surprisingly, a category with low/absent WWP1 expression displayed a consistently worse prognosis compared with WWPl-expressing tumours. Importantly, the association with disease-free survival was independent of the status of other commonly used prognostic indicators. Thus, WWP1 is a prognostic marker and may be a potential therapeutic target for a subset of breast tumours. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. | |
dc.publisher | John Wiley & Sons Ltd | |
dc.title | Tumour-promoting activity of altered WWPI expression in breast cancer and its utility as a prognostic indicator | |
dc.type | Journal Article | |
dcterms.source.volume | 216 | |
dcterms.source.number | 1 | |
dcterms.source.startPage | 93 | |
dcterms.source.endPage | 102 | |
dcterms.source.issn | 0022-3417 | |
dcterms.source.title | Journal of Pathology | |
curtin.accessStatus | Fulltext not available |
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