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dc.contributor.authorHuu, N.
dc.contributor.authorRyder, W.
dc.contributor.authorZeps, Nikolajs
dc.contributor.authorFlasza, M.
dc.contributor.authorChiu, M.
dc.contributor.authorHanby, A.
dc.contributor.authorPoulsom, R.
dc.contributor.authorClarke, R.
dc.contributor.authorBaron, M.
dc.date.accessioned2017-01-30T14:37:04Z
dc.date.available2017-01-30T14:37:04Z
dc.date.created2016-09-12T08:36:43Z
dc.date.issued2008
dc.identifier.citationHuu, N. and Ryder, W. and Zeps, N. and Flasza, M. and Chiu, M. and Hanby, A. and Poulsom, R. et al. 2008. Tumour-promoting activity of altered WWPI expression in breast cancer and its utility as a prognostic indicator. Journal of Pathology. 216 (1): pp. 93-102.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/39791
dc.identifier.doi10.1002/path.2385
dc.description.abstract

WWP1 is a ubiquitin ligase, associated with the post-translational regulation of several tumour-promoting and tumour suppressor proteins. Here we show that WWP1 expression is up-regulated in a subset of breast tumour cell lines and primary breast tumours. We overexpressed WWP1 in MCF10A breast epithelial cells and demonstrated increased cell growth and anchorage- independent colony formation. RNAi knockdown of WWP1 expression in T47D and MCF7 breast tumour cell lines reduced anchorage-independent colony formation. We used WWP1 protein expression levels, in combination with its subcellular localization, to classify breast tumours into four categories. Surprisingly, a category with low/absent WWP1 expression displayed a consistently worse prognosis compared with WWPl-expressing tumours. Importantly, the association with disease-free survival was independent of the status of other commonly used prognostic indicators. Thus, WWP1 is a prognostic marker and may be a potential therapeutic target for a subset of breast tumours. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

dc.publisherJohn Wiley & Sons Ltd
dc.titleTumour-promoting activity of altered WWPI expression in breast cancer and its utility as a prognostic indicator
dc.typeJournal Article
dcterms.source.volume216
dcterms.source.number1
dcterms.source.startPage93
dcterms.source.endPage102
dcterms.source.issn0022-3417
dcterms.source.titleJournal of Pathology
curtin.accessStatusFulltext not available


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