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Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges

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Paterson, S.
Shadforth, A.
Shaw, J.
Brown, David
Chirila, T.
Baker, M.
Date
2013
Type
Journal Article

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Paterson, Stefan M. and Shadforth, Audra M. A. and Shaw, Jeremy A. and Brown, David H. and Chirila, Traian V. and Baker, Murray V. 2013. Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges. Materials Science and Engineering: C. 33 (8): pp. 4917-4922.
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Materials Science and Engineering C
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NOTICE: This is the author’s version of a work that was accepted for publication in Materials Science and Engineering: C. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Science and Engineering: C, Volume 33, Issue 8, December 2013, Pages 4917-4922. http://dx.doi.org/10.1016/j.msec.2013.08.011

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Abstract

A monomer that contained the RGD ligand motif was synthesized and copolymerized with 2-hydroxyethyl methacrylate using polymerization-induced phase separation methods to form poly(2-hydroxyethyl methacrylate)-based hydrogel sponges. The sponges had morphologies of aggregated polymer droplets and interconnected pores, the pores having dimensions in the order of 10 µm typical of PHEMA sponges. RGD-containing moieties appeared to be evenly distributed through the polymer droplets. Compared to PHEMA sponges that were not functionalized with RGD, the new sponges containing RGD allowed greater invasion by human corneal epithelial cells, by advancing the attachment of cells to the surface of the polymer droplets.