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dc.contributor.authorAffandi, J.
dc.contributor.authorAghafar, Z.
dc.contributor.authorRodriguez, B.
dc.contributor.authorLederman, M.
dc.contributor.authorBurrows, S.
dc.contributor.authorSenitzer, D.
dc.contributor.authorPrice, Patricia
dc.date.accessioned2017-01-30T14:41:15Z
dc.date.available2017-01-30T14:41:15Z
dc.date.created2015-10-29T04:10:07Z
dc.date.issued2012
dc.identifier.citationAffandi, J. and Aghafar, Z. and Rodriguez, B. and Lederman, M. and Burrows, S. and Senitzer, D. and Price, P. 2012. Can immune-related genotypes illuminate the immunopathogenesis of cytomegalovirus disease in human immunodeficiency virus-infected patients?. Human Immunology. 73 (2): pp. 168-174.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/40290
dc.identifier.doi10.1016/j.humimm.2011.11.005
dc.description.abstract

Most human immunodeficiency virus (HIV) patients are seropositive for cytomegalovirus (CMV) but a smaller proportion experience end-organ disease. This observation may reflect variations in genes affecting inflammatory and natural killer cell responses. DNA samples were collected from 240 HIV-infected patients followed at the University Hospitals/Case Medical Center (Cleveland, OH) between 1993 and 2008. Seventy-eight patients (African Americans = 41, Caucasians = 37) experienced CMV disease. Genotypes were determined using allele-specific fluorescent probes or multiplex polymerase chain reaction sequence-specific primers. IL12B3'UTR*(1) and SLC11A1 D543N*(1,2) were associated with CMV disease in African American patients (p = 0.04 and p = 0.02, respectively). IL10-1082*(1,2) and LILRB1 I142T*(1) were associated with CMV disease in Caucasians (p = 0.02 and p = 0.07, respectively). DARC T-46C*(1) and CD14 C-159T*(2) were associated with low nadir CD4 + T cell counts in African American patients (p = 0.002 and p = 0.01, respectively). Caucasian patients carrying TNFA-308*2, TNFA-1031*(2), IL2-330*(1), CCL2-2518*(2), or LILRB1 I142T*(1) had significantly lower nadir CD4 + T cells in a bootstrapped multivariable model (p = 0.006-0.02). In general, polymorphisms associated with CMV disease and CD4 + T cell counts were distinct in Caucasian and African American patients in the United States. The LILRB1 I142T polymorphism was associated with both CMV disease and low nadir CD4 + T cell counts in Caucasians, but the clearest determinant of low nadir CD4 + T cell count in African American patients was DARC T-46C. © 2012 American Society for Histocompatibility and Immunogenetics.

dc.titleCan immune-related genotypes illuminate the immunopathogenesis of cytomegalovirus disease in human immunodeficiency virus-infected patients?
dc.typeJournal Article
dcterms.source.volume73
dcterms.source.number2
dcterms.source.startPage168
dcterms.source.endPage174
dcterms.source.issn0198-8859
dcterms.source.titleHuman Immunology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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