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    A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients

    Access Status
    Fulltext not available
    Authors
    Wadley, A.
    Kamerman, P.
    Chew, C.
    Lombard, Z.
    Cherry, C.
    Price, Patricia
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Wadley, A. and Kamerman, P. and Chew, C. and Lombard, Z. and Cherry, C. and Price, P. 2013. A polymorphism in IL4 may associate with sensory neuropathy in African HIV patients. Molecular Immunology. 55 (3-4): pp. 197-199.
    Source Title
    Molecular Immunology
    DOI
    10.1016/j.molimm.2013.02.002
    ISSN
    0161-5890
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/30435
    Collection
    • Curtin Research Publications
    Abstract

    Introduction Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. Method 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. Results IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. Discussion We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation. © 2013 Elsevier Ltd.

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