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dc.contributor.authorLucey, Anthony
dc.contributor.authorKing, Andrew
dc.contributor.authorTetlow, G.
dc.contributor.authorWang, Jian De
dc.contributor.authorArmstrong, J.
dc.contributor.authorLeigh, M.
dc.contributor.authorPaduch, A.
dc.contributor.authorWalsh, J.
dc.contributor.authorSampson, D.
dc.contributor.authorEastwood, P.
dc.contributor.authorHillman, D.
dc.identifier.citationLucey, A. D. and King, A. J. C. and Tetlow, G. A. and Wang, J. and Armstrong, J.J. and Leigh, M. S. and Paduch, A. and Walsh, J. H. and Sampson, D. D. and Eastwood, P. R. and Hillman, D. R. 2010. Measurement, reconstruction and flow-field computation of the human pharynx with application to sleep apnea. IEEE Transactions on Biomedical Engineering. 57 (10): pp. 2535-2548.

Repetitive closure of the upper airway characterizes obstructive sleep apnea. It disrupts sleep causing excessive daytime drowsiness and is linked to hypertension and cardiovascular disease. Previous studies simulating the underlying fluid mechanics are based upon geometries, time-averaged over the respiratory cycle, obtained usually via MRI or CT scans. Here, we generate an anatomically correct geometry from data captured in vivo by an endoscopic optical technique. This allows quantitative real-time imaging of the internal cross section with minimal invasiveness. The steady inhalation flow field is computed using a k-ω shear-stress transport (SST) turbulence model. Simulations reveal flow mechanisms that produce low-pressure regions on the sidewalls of the pharynx and on the soft palate within the pharyngeal section of minimum area. Soft-palate displacement and side-wall deformations further reduce the pressures in these regions, thus creating forces that would tend to narrow the airway. These phenomena suggest a mechanism for airway closure in the lateral direction as clinically observed. Correlations between pressure and airway deformation indicate that quantitative prediction of the low-pressure regions for an individual are possible. The present predictions warrant and can guide clinical investigation to confirm the phenomenology and its quantification, while the overall approach represents an advancement toward patient-specific modeling.

dc.subjectComputational fluid dynamics
dc.subjectsleep apnea
dc.subjectoptical coherence tomography (OCT)
dc.subjectimage processing
dc.subjectupper airway anatomy
dc.titleMeasurement, reconstruction and flow-field computation of the human pharynx with application to sleep apnea
dc.typeJournal Article
dcterms.source.titleIEEE Transactions on Biomedical Engineering
curtin.departmentDepartment of Mechanical Engineering
curtin.accessStatusFulltext not available

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