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dc.contributor.authorIles, M.
dc.contributor.authorBishop, D.
dc.contributor.authorTaylor, J.
dc.contributor.authorHayward, N.
dc.contributor.authorBrossard, M.
dc.contributor.authorCust, A.
dc.contributor.authorDunning, A.
dc.contributor.authorLee, J.
dc.contributor.authorMoses, Eric
dc.contributor.authorAkslen, L.
dc.contributor.authorAndresen, P.
dc.contributor.authorAvril, M.
dc.contributor.authorAzizi, E.
dc.contributor.authorScarra, G.
dc.contributor.authorBrown, K.
dc.contributor.authorDebniak, T.
dc.contributor.authorElder, D.
dc.contributor.authorFriedman, E.
dc.contributor.authorGhiorzo, P.
dc.contributor.authorGillanders, E.
dc.contributor.authorGoldstein, A.
dc.contributor.authorGruis, N.
dc.contributor.authorHansson, J.
dc.contributor.authorHarland, M.
dc.contributor.authorHelsing, P.
dc.contributor.authorHoçevar, M.
dc.contributor.authorHoiom, V.
dc.contributor.authorIngvar, C.
dc.contributor.authorKanetsky, P.
dc.contributor.authorLandi, M.
dc.contributor.authorLang, J.
dc.contributor.authorLathrop, G.
dc.contributor.authorLubinski, J.
dc.contributor.authorMackie, R.
dc.contributor.authorMartin, N.
dc.contributor.authorMolven, A.
dc.contributor.authorMontgomery, G.
dc.contributor.authorNovakovi, S.
dc.contributor.authorOlsson, H.
dc.contributor.authorPuig, S.
dc.contributor.authorPuig-Butille, J.
dc.contributor.authorRadford-Smith, G.
dc.contributor.authorRanderson-Moor, J.
dc.contributor.authorVan Der Stoep, N.
dc.contributor.authorVan Doorn, R.
dc.contributor.authorWhiteman, D.
dc.contributor.authorMacgregor, S.
dc.contributor.authorPooley, K.
dc.contributor.authorWard, S.
dc.contributor.authorMann, G.
dc.contributor.authorAmos, C.
dc.contributor.authorPharoah, P.
dc.contributor.authorDemenais, F.
dc.contributor.authorLaw, M.
dc.contributor.authorBishop, J.
dc.contributor.authorBarrett, J.
dc.date.accessioned2017-01-30T14:46:28Z
dc.date.available2017-01-30T14:46:28Z
dc.date.created2016-01-20T20:00:35Z
dc.date.issued2014
dc.identifier.citationIles, M. and Bishop, D. and Taylor, J. and Hayward, N. and Brossard, M. and Cust, A. and Dunning, A. et al. 2014. The effect on melanoma risk of genes previously associated with telomere length. Journal of the National Cancer Institute. 106 (10): dju267.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/40881
dc.identifier.doi10.1093/jnci/dju267
dc.description.abstract

Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10-9, two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.

dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.titleThe effect on melanoma risk of genes previously associated with telomere length
dc.typeJournal Article
dcterms.source.volume106
dcterms.source.number10
dcterms.source.issn0027-8874
dcterms.source.titleJournal of the National Cancer Institute
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher


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