Screening for Down syndrome in the second trimester of pregnancy.
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Antenatal screening for fetal anomalies has provided women and their partners with information to make reproductive choices based on the risk of serious chromosomal or structural defects since the 1990s. Alternative tests include first-trimester screening (combined ultrasound and maternal serum markers), second-trimester maternal serum markers and noninvasive cell-free DNA testing. The recent recommendations by the Royal Australian and New Zealand College of Obstetrics and Gynaecology and the Human Genetics Society of Australasia against second-trimester triple testing are based on unsound performance criteria, raise several contestable issues around access and equity and challenge the principles of governments providing affordable options.
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The relationship of maternal micronutrient intakes of Vitamin B12, vitamin B6, folate and calcium on intrauterine growth retardation and birth weight : a prospective cohort study of urban South Indian pregnant womenDwarkanath, Pratibha (2011)The period of intrauterine growth and development is one of the most vulnerable periods in the human life cycle. The weight of the infant at birth is a powerful predictor of infant growth and survival, and is ...
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Prenatal screening for Down Syndrome in Australia: costs and benefits of current and novel screening strategiesO'Leary, Peter; Maxwell, S.; Murch, A.; Hendrie, Delia (2013)OBJECTIVE: To analyse the cost-effectiveness and performance of noninvasive prenatal testing (NIPT) for high-risk pregnancies following first-trimester screening compared with current practice.METHODS: A decision tree ...