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    Glutamine and skeletal muscle

    Access Status
    Fulltext not available
    Authors
    Tirapegui, J.
    Cruzat, Vinicius
    Date
    2015
    Type
    Book Chapter
    
    Metadata
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    Citation
    Tirapegui, J. and Cruzat, V. 2015. Glutamine and skeletal muscle, in Rajendram, R. And Preedy, V. and Patgel, V. (ed), Glutamine in Clinical Nutrition, pp. 499-511. New York: Springer.
    Source Title
    Glutamine in Clinical Nutrition
    DOI
    10.1007/978-1-4939-1932-1_38
    ISBN
    9781493919314
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/41943
    Collection
    • Curtin Research Publications
    Abstract

    Of the group of 20 amino acids which covalently bonded in linear sequences to form all proteins from the oldest bacteria to the most complex forms of life, glutamine deserves special attention. For many mammals, including human beings, glutamine, especially intermediate metabolism of amino acids of muscle cells, is the most abundant free amino acid in the body and is important in many cell types, playing an important role in a number of essential functions. In high catabolism conditions, such as diseases and exhausting exercise, the synthesis of glutamine does not supply the needs demanded by the organism. In this process, one of the most important sites of glutamine synthesis is the skeletal muscle, not for its synthesis capacity per se, but because it represents at least 40 % of total bodily mass.

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    • Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise
      Cruzat, Vinicius; Rogero, M.; Tirapegui, J. (2010)
      In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle damage and levels of ...
    • L-glutamine and L-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27 in rats trained using a progressive high-intensity resistance exercise
      Leite, J.; Raizel, R.; Hypólito, T.; Dos Santos Rosa, T.; Cruzat, Vinicius; Tirapegui, J. (2016)
      In this study we investigated the chronic effects of oral L-glutamine and L-alanine supplementation, either in their free or dipeptide form, on glutamine-glutathione (GLN-GSH) axis and cytoprotection mediated by HSP-27 ...
    • Glutamine: Metabolism and immune function, supplementation and clinical translation
      Cruzat, Vinicius; Rogero, M.; Keane, Kevin; Curi, R.; Newsholme, Philip (2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Glutamine is the most abundant and versatile amino acid in the body. In health and disease, the rate of glutamine consumption by immune cells is similar or greater ...
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