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    Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise

    Access Status
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    Authors
    Cruzat, Vinicius
    Rogero, M.
    Tirapegui, J.
    Date
    2010
    Type
    Journal Article
    
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    Citation
    Cruzat, V. and Rogero, M. and Tirapegui, J. 2010. Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise. Cell Biochemistry and Function. 28 (1): pp. 24-30.
    Source Title
    Cell Biochemistry and Function
    DOI
    10.1002/cbf.1611
    ISSN
    0263-6484
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/23729
    Collection
    • Curtin Research Publications
    Abstract

    In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle damage and levels of pro-inflammatory cytokines and glutamine metabolism in rats submitted to prolonged exercise. Rats were submitted to sessions of swim training for 6 weeks. Twenty-one days prior to euthanasia, the animals were supplemented with DIP (n=8) (1.5 g.kg-1), a solution of free L-glutamine (1 g.kg -1) and free L-alanine (0.61 g.kg-1) (G&A, n=8) or water (control (CON), n=8). Animals were killed at rest before (R), after prolonged exercise (PE - 2 h of exercise). Plasma concentrations of glutamine, glutamate, tumour necrosis factor-a (TNF-a), prostaglandin E2 (PGE2) and activity of creatine kinase (CK), lactate dehydrogenase (LDH) and muscle concentrations of glutamine and glutamate were measured. The concentrations of plasma TNF-a, PGE2 and the activity of CK were lower in the G&A-R and DIP-R groups, compared to the CON-R. Glutamine in plasma ( p<0.04) and soleus muscle (p<0.001) was higher in the DIP-R and G&A-R groups relative to the CON-R group. G&A-PE and DIP-PE groups exhibited lower concentrations of plasma PGE2 ( p<0.05) and TNF-a (p<0.05), and higher concentrations of glutamine and glutamate in soleus (p<0.001) and gastrocnemius muscles ( p<0.05) relative to the CON-PE group. We concluded that supplementation with free L-glutamine and the dipeptide LL-alanyl-LL-glutamine represents an effective source of glutamine, which may attenuate inflammation biomarkers after periods of training and plasma levels of CK and the inflammatory response induced by prolonged exercise. Copyright © 2009 John Wiley & Sons, Ltd.

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    • L-glutamine and L-alanine supplementation increase glutamine-glutathione axis and muscle HSP-27 in rats trained using a progressive high-intensity resistance exercise
      Leite, J.; Raizel, R.; Hypólito, T.; Dos Santos Rosa, T.; Cruzat, Vinicius; Tirapegui, J. (2016)
      In this study we investigated the chronic effects of oral L-glutamine and L-alanine supplementation, either in their free or dipeptide form, on glutamine-glutathione (GLN-GSH) axis and cytoprotection mediated by HSP-27 ...
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      Cruzat, Vinicius; Tirapegui, J. (2009)
      Objective: We investigated the effect of supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine, both in the free form, on the plasma and tissue concentrations ...
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      Raizel, R.; Leite, J.; Hypólito, T.; Coqueiro, A.; Newsholme, Philip; Cruzat, Vinicius; Tirapegui, J. (2016)
      We evaluated the effects of chronic oral supplementation with l-glutamine and l-alanine in their free form or as the dipeptide l-alanyl-l-glutamine (DIP) on muscle damage, inflammation and cytoprotection, in rats submitted ...
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