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    Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity

    Access Status
    Fulltext not available
    Authors
    Dubey, A.
    Bharadwaj, Prashant
    Varghese, J.
    MacReadie, I.
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Dubey, A. and Bharadwaj, P. and Varghese, J. and MacReadie, I. 2009. Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity. Journal of Alzheimer's Disease. 18 (1): pp. 31-33.
    Source Title
    Journal of Alzheimer's Disease
    DOI
    10.3233/JAD-2009-1121
    ISSN
    1387-2877
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/42488
    Collection
    • Curtin Research Publications
    Abstract

    Amyloid-ß (Aß-{42}), which is known to be toxic to neuronal cells, protects yeast cells from severe sodium hydroxide toxicity. More than 85% cell death was caused by treatment with 1 mM NaOH and approximately 95% was observed at a 2 mM concentration. However, greater than 55% cells survived the treatment in the presence of Aß-{42}. A strong protective effect of the peptide was also evident from the differential staining of the treated culture with propidium iodide. © 2009 - IOS Press and the authors. All rights reserved.

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