Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity
Abstract
Amyloid-ß (Aß-{42}), which is known to be toxic to neuronal cells, protects yeast cells from severe sodium hydroxide toxicity. More than 85% cell death was caused by treatment with 1 mM NaOH and approximately 95% was observed at a 2 mM concentration. However, greater than 55% cells survived the treatment in the presence of Aß-{42}. A strong protective effect of the peptide was also evident from the differential staining of the treated culture with propidium iodide. © 2009 - IOS Press and the authors. All rights reserved.
Citation
Dubey, A. and Bharadwaj, P. and Varghese, J. and MacReadie, I. 2009. Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity. Journal of Alzheimer's Disease. 18 (1): pp. 31-33.
Source Title
Journal of Alzheimer's Disease
ISSN
School
School of Biomedical Sciences
Collection
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