Alzheimer's amyloid-ß rescues yeast from hydroxide toxicity

Abstract

Amyloid-ß (Aß-{42}), which is known to be toxic to neuronal cells, protects yeast cells from severe sodium hydroxide toxicity. More than 85% cell death was caused by treatment with 1 mM NaOH and approximately 95% was observed at a 2 mM concentration. However, greater than 55% cells survived the treatment in the presence of Aß-{42}. A strong protective effect of the peptide was also evident from the differential staining of the treated culture with propidium iodide. © 2009 - IOS Press and the authors. All rights reserved.