Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Effect of the incorporation of hydroxy-terminated liquid silicones on the cure characteristics, morphology and release of a model protein from silicone elastomer covered rods

    Access Status
    Fulltext not available
    Authors
    McConville, Christopher
    Andrews, G.
    Woolfson, A.
    Malcolm, R.
    Date
    2011
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    McConville, Christopher and Andrews, Gavin P. and Woolfson, A. David and Malcolm, R. Karl. 2011. Effect of the incorporation of hydroxy-terminated liquid silicones on the cure characteristics, morphology and release of a model protein from silicone elastomer covered rods. Journal of Applied Polymer Science. 124: pp. 805-812.
    Source Title
    Journal of Applied Polymer Science
    DOI
    10.1002/app.35080
    ISSN
    0021-8995
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/43153
    Collection
    • Curtin Research Publications
    Abstract

    Silicone elastomer systems have previously been shown to offer potential for the sustained release of protein therapeutics. However, the general requirement for the incorporation of large amounts of release enhancing solid excipients to achieve therapeutically effective release rates from these otherwise hydrophobic polymer systems can detrimentally affect the viscosity of the precure silicone elastomer mixture and its curing characteristics. The increase in viscosity necessitates the use of higher operating pressures in manufacture, resulting in higher shear stresses that are often detrimental to the structural integrity of the incorporated protein. The addition of liquid silicones increases the initial tan δ value and the tan δ values in the early stages of curing by increasing the liquid character (G″) of the silicone elastomer system and reducing its elastic character (G′), thereby reducing the shear stress placed on the formulation during manufacture and minimizing the potential for protein degradation. However, SEM analysis has demonstrated that if the liquid character of the silicone elastomer is too high, the formulation will be unable to fill the mold during manufacture. This study demonstrates that incorporation of liquid hydroxy-terminated polydimethylsiloxanes into addition-cure silicone elastomer-covered rod formulations can both effectively lower the viscosity of the precured silicone elastomer and enhance the release rate of the model therapeutic protein bovine serum albumin.

    Related items

    Showing items related by title, author, creator and subject.

    • Studies of fly ash-based geopolymer concrete
      Hardjito, Djwantoro (2005)
      The use of Portland cement in concrete construction is under critical review due to high amount of carbon dioxide gas released to the atmosphere during the production of cement. In recent years, attempts to increase the ...
    • Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings
      McConville, Christopher; Major, Ian; Friend, David; Clark, Meredith; Woolfson, A; Malcolm, R (2012)
      Vaginal rings are currently being investigated for delivery of HIV microbicides. However, vaginal rings are currently manufactured form hydrophobic polymers such as silicone elastomer and polyethylene vinyl acetate (PEVA), ...
    • Synthesis and evaluation of porous composite hydrogels for tissue engineering applications
      Li, Chao (2012)
      The purpose of this dissertation was to synthesize and evaluate porous poly(2- hydroxyethyl methacrylate) (PHEMA) and PHEMA composite hydrogels containing various concentrations of titanium dioxide (TiO2) nanoparticles, ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.