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    ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma

    Access Status
    Fulltext not available
    Authors
    Martin, A.
    Zhang, Guicheng
    Rueter, K.
    Khoo, S.
    Bizzintino, J.
    Hayden, C.
    Geelhoed, G.
    Goldblatt, J.
    Laing, I.
    Le Souëf, P.
    Date
    2008
    Type
    Journal Article
    
    Metadata
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    Citation
    Martin, A. and Zhang, G. and Rueter, K. and Khoo, S. and Bizzintino, J. and Hayden, C. and Geelhoed, G. et al. 2008. ß2-adrenoceptor polymorphisms predict response to ß2-agonists in children with acute asthma. Journal of Asthma. 45 (5): pp. 383-388.
    Source Title
    Journal of Asthma
    DOI
    10.1080/02770900801971792
    ISSN
    0277-0903
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/43182
    Collection
    • Curtin Research Publications
    Abstract

    The aim of this study was to determine the influence of single nucleotide polymorphisms in the ß2-adrenoceptor gene, on the response to inhaled ß2-agonists in children with acute asthma. We hypothesised that children with polymorphisms that generate enhanced receptor downregulation in vitro, Gly16 and Gln27, would have a slower response to ß2-agonist therapy during acute asthma. One hundred and forty-eight children with acute asthma were recruited and genotyped for ß2Arg16Gly and ß2Gln27Glu. For Gln27Glu, individuals Gln27Gln took longest to stretch out to 1, 2 and 4 hourly ß2-agonists, followed by heterozygotes who were intermediate and Glu27Glu who responded most rapidly (1hourly: 2.6hr vs. 2.0 vs. 1.4, p = 0.02; 2 hourly: 10.6hr vs. 10.7 vs. 6.8, p = 0.07; 4 hourly: 29.8hr vs. 28.5 vs. 24.3, p = 0.30). The ability to prospectively identify children who respond less effectively to ß 2-agonists during an acute asthma attack has the potential to allow the generation of genotype-specific treatment pathways. Copyright © 2008 Informa Healthcare USA, Inc.

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