An ontology-based segmentation scheme for tracking postnatal changes in the developing rodent brain with MRI
Abstract
The postnatal period of neurodevelopment has been implicated in a number of brain disorders including autism and schizophrenia. Rodent models have proven to be invaluable in advancing our understanding of the human brain, and will almost certainly play a pivotal role in future studies on postnatal neurodevelopment. The growing field of magnetic resonance microscopy has the potential to revolutionize our understanding of neurodevelopment, if it can be successfully and appropriately assimilated into the vast body of existing neuroscience research. In this study, we demonstrate the utility of a developmental neuro-ontology designed specifically for tracking regional changes in MR biomarkers throughout postnatal neurodevelopment. Using this ontological classification as a segmentation guide, we track regional changes in brain volume in rats between postnatal day zero and postnatal day 80 and demonstrate differential growth rates in axial versus paraxial brain regions. Both the ontology and the associated label volumes are provided as a foundation for future MR-based studies of postnatal neurodevelopment in normal and disease states.
Citation
Source Title
ISSN
Remarks
NOTICE: This is the author’s version of a work that was accepted for publication in NeuroImage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in, NeuroImage, Vol. 67, (2013). http://doi.org/10.1016/j.neuroimage.2012.11.037
Collection
Related items
Showing items related by title, author, creator and subject.
-
Calabrese, E.; Badea, A.; Watson, Charles; Johnson, G. (2013)There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the ...
-
Duan, D.; Fu, Y.; Paxinos, G.; Watson, Charles (2012)The transcription factor Pax6 has been reported to specify neural progenitor cell fates during development and maintain neuronal commitments in the adult. The spatiotemporal patterns of Pax6 expression were examined in ...
-
Szulc, K.; Lerch, J.; Nieman, B.; Bartelle, B.; Friedel, M.; Suero-Abreu, G.; Watson, Charles; Joyner, A.; Turnbull, D. (2015)The widespread use of the mouse as a model system to study brain development has created the need for noninvasive neuroimaging methods that can be applied to early postnatal mice. The goal of this study was to optimize ...