A quantitative magnetic resonance histology atlas of rat brain development with regional estimates of growth and variability
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NOTICE: This is the author’s version of a work that was accepted for publication in NeuroImage. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in NeuroImage, Vol. 71. (2013). doi: 10.1016/j.neuroimage.2013.01.017
There has been growing interest in the role of postnatal brain development in the etiology of several neurologic diseases. The rat has long been recognized as a powerful model system for studying neuropathology and the safety of pharmacologic treatments. However, the complex spatiotemporal changes that occur during rat neurodevelopment remain to be elucidated. This work establishes the first magnetic resonance histology (MRH) atlas of the developing rat brain, with an emphasis on quantitation. The atlas comprises five specimens at each of nine time points, imaged with eight distinct MR contrasts and segmented into 26 developmentally defined brain regions. The atlas was used to establish a timeline of morphometric changes and variability throughout neurodevelopment and represents a quantitative database of rat neurodevelopment for characterizing rat models of human neurologic disease.
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Shen, K.; Fripp, J.; Pannek, K.; George, J.; Colditz, P.; Boyd, Roslyn; Rose, S. (2017)© 2017 IEEE. Spatio-temporal atlas is a useful tool in imaging studies of neurodevelopment, which characterizes the growth of brain, and allows the monitoring of its development. The imaging of preterm and term born infants ...
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