Show simple item record

dc.contributor.authorShao, P.
dc.contributor.authorLiu, J.
dc.contributor.authorChen, X.
dc.contributor.authorFang, Zhongxiang
dc.contributor.authorSun, P.
dc.identifier.citationShao, P. and Liu, J. and Chen, X. and Fang, Z. and Sun, P. 2015. Structural features and antitumor activity of a purified polysaccharide extracted from Sargassum horneri. International Journal of Biological Macromolecules. 73: pp. 124-130.

A polysaccharide fraction (SHPSA) was obtained from Sargassum horneri by hot-water extraction and sequential purification of anion-exchange chromatography and gel-filtration chromatography. SHPSA was found to be a neutral polysaccharide fraction with an average molecular weight of 5.78 × 105 Da and composed of T-d-Glcp, 1,3-d-Glcp, 1,6-d-Glcp and 1,3,6-d-Glcp in a molar percentage of 1.00:4.17:1.17:0.89, respectively. Based on the results from chemical analysis, NMR, and SHPSA was determined to be a glucan with β-(1 → 6) side chains linked to a β-(1 → 3) backbone with relatively few branch points. Moreover, SHPSA could inhibit the growth of human colon cancer DLD cells in a dose-dependent manner by inducing the apoptosis of DLD cells. So, SHPSA was promising for future use as a natural antitumor agent.

dc.titleStructural features and antitumor activity of a purified polysaccharide extracted from Sargassum horneri
dc.typeJournal Article
dcterms.source.titleInternational Journal of Biological Macromolecules
curtin.departmentSchool of Public Health
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record