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    Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

    235574_235574.pdf (585.6Kb)
    Access Status
    Open access
    Authors
    Goozee, K.
    Shah, T.
    Sohrabi, H.
    Rainey-Smith, S.
    Brown, B.
    Verdile, Giuseppe
    Martins, R.
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Goozee, K. and Shah, T. and Sohrabi, H. and Rainey-Smith, S. and Brown, B. and Verdile, G. and Martins, R. 2015. Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease. British Journal of Nutrition. 115 (3): pp. 449-465.
    Source Title
    British Journal of Nutrition
    DOI
    10.1017/S0007114515004687
    ISSN
    0007-1145
    School
    School of Biomedical Sciences
    Remarks

    This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    URI
    http://hdl.handle.net/20.500.11937/43982
    Collection
    • Curtin Research Publications
    Abstract

    Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties that may help delay or prevent neurodegenerative diseases, including Alzheimer’s disease (AD). Currently, clinical diagnosis of AD is onerous, and it is primarily based on the exclusion of other causes of dementia. In addition, phase III clinical trials of potential treatments have mostly failed, leaving disease-modifying interventions elusive. AD can be characterised neuropathologically by the deposition of extracellular ß amyloid (Aß) plaques and intracellular accumulation of tau-containing neurofibrillary tangles. Disruptions in Aß metabolism/clearance contribute to AD pathogenesis. In vitro studies have shown that Aß metabolism is altered by curcumin, and animal studies report that curcumin may influence brain function and the development of dementia, because of its antioxidant and anti-inflammatory properties, as well as its ability to influence Aß metabolism. However, clinical studies of curcumin have revealed limited effects to date, most likely because of curcumin’s relatively low solubility and bioavailability, and because of selection of cohorts with diagnosed AD, in whom there is already major neuropathology. However, the fresh approach of targeting early AD pathology (by treating healthy, pre-clinical and mild cognitive impairment-stage cohorts) combined with new curcumin formulations that increase bioavailability is renewing optimism concerning curcumin-based therapy. The aim of this paper is to review the current evidence supporting an association between curcumin and modulation of AD pathology, including in vitro and in vivo studies. We also review the use of curcumin in emerging retinal imaging technology, as a fluorochrome for AD diagnostics.

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