Show simple item record

dc.contributor.authorAsih, P.
dc.contributor.authorChatterjee, P.
dc.contributor.authorVerdile, Giuseppe
dc.contributor.authorGupta, V.
dc.contributor.authorTrengrove, R.
dc.contributor.authorMartins, R.
dc.date.accessioned2017-01-30T15:14:25Z
dc.date.available2017-01-30T15:14:25Z
dc.date.created2015-05-22T08:32:02Z
dc.date.issued2014
dc.identifier.citationAsih, P. and Chatterjee, P. and Verdile, G. and Gupta, V. and Trengrove, R. and Martins, R. 2014. Clearing the amyloid in Alzheimer's: progress towards earlier diagnosis and effective treatments - an update for clinicians. Neurodegenerative Disease Management. 4 (5): pp. 363-378.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/44496
dc.identifier.doi10.2217/NMT.14.29
dc.description.abstract

A beta (Aβ or β-amyloid) is a key molecule in Alzheimer's disease (AD) pathogenesis. According to the ‘amyloid hypothesis’, the gradual accumulation of Aβ triggers events which results in neuronal loss in regions of the brain involved with memory and learning. Diverse agents have been developed to reduce brain Aβ accumulation or to enhance its clearance. Some have progressed to human trials, however all have failed to improve cognition in patients. This has led researchers to question whether Aβ is really the problem. However, the trials have been targeting end stages of AD, by which stage extensive irreversible neuronal damage has already occurred. Intervention is required preclinically, therefore preclinical AD biomarkers are needed. In this regard, amyloid imaging and cerebrospinal fluid biomarkers are leading the way, with plasma biomarkers and eye tests also being investigated. This review covers the current state of knowledge of Aβ as an early diagnostic biomarker and as a therapeutic target in AD.

dc.publisherFuture Medicine
dc.subjectCSF
dc.subjectPET amyloid imaging
dc.subjectretinal photography
dc.subjectanti-amyloid
dc.subjectlifestyle
dc.subjectType 2 diabetes
dc.subjectbiomarkers
dc.subjectamyloid
dc.subjectplasma biomarkers
dc.subjectdrug
dc.titleClearing the amyloid in Alzheimer's: progress towards earlier diagnosis and effective treatments - an update for clinicians.
dc.typeJournal Article
dcterms.source.volume4
dcterms.source.number5
dcterms.source.startPage363
dcterms.source.endPage378
dcterms.source.issn1758-2024
dcterms.source.titleNeurodegenerative Disease Management
curtin.accessStatusFulltext not available


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record