A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation

Lim, Felicia Phei Lin; Luna, Giuseppe; Dolzhenko, Anton

doi:10.1016/j.tetlet.2014.07.105

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Authors

Lim, Felicia Phei Lin

Luna, Giuseppe

Dolzhenko, Anton

Date

2014

Type

Journal Article

Metadata

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Citation

Lim, F.P.L. and Luna, G. and Dolzhenko, A. 2014. A new, one-pot, multicomponent synthesis of 5-aza-9-deaza-adenines under microwave irradiation. Tetrahedron Letters. 55 (37): pp. 5159-5163.

Source Title

Tetrahedron Letters

DOI

10.1016/j.tetlet.2014.07.105

ISSN

0040-4039

School

School of Pharmacy

URI

http://hdl.handle.net/20.500.11937/44673

Collection

Curtin Research Publications

Abstract

A new, practical, three-component method for the synthesis of 5-aza-9-deaza-adenines is developed. Aminopyrazoles react in a one-pot fashion with triethyl orthoformate and cyanamide under microwave irradiation affording 5-aza-9-deaza-adenines in good yields and high purity. The main advantages of this method are the operational simplicity, accessibility and high efficiency