Confirmed case of encephalitis caused by Murray Valley encephalitis virus infection in a horse
MetadataShow full item record
The final, definitive version of this paper has been published in Journal of Veterinary Diagnostic Investigation, 24 (2), March 2012 by SAGE Publications Ltd, All rights reserved. © Anita N. Gordon
A five year old Australian stock horse in Monto, Queensland, developed neurological signs and was euthanized after a six day course of illness. Histological examination of the brain and spinal cord revealed moderate to severe, subacute, non-suppurative encephalomyelitis. Sections of spinal cord stained positively in immunohistochemistry with a flavivirus-specific monoclonal antibody. Reverse transcription-polymerase chain reaction assay targeting the envelope gene of flavivirus yielded positive results from brain, spinal cord, cerebrospinal fluid and facial nerve. A flavivirus was isolated from the cerebrum and spinal cord. Nucleotide sequences obtained from amplicons from both tissues and virus isolated in cell culture were compared with those in GenBank, and had 96-98% identity with Murray Valley encephalitis virus. The partial envelope gene sequence of the viral isolate clustered into Genotype 1, and was most closely related to a previous Queensland isolate. This is the first confirmed case of naturally-occurring equine encephalitis attributable to Murray Valley encephalitis virus infection.
Showing items related by title, author, creator and subject.
Rainfall and sentinel chicken seroconversions predict human cases of Murray Valley encephalitis in the north of Western AustraliaSelvey, Linda; Johansen, C.; Broom, A.; Antao, Catarina; Lindsay, M.; Mackenzie, John; Smith, D. (2014)Background Murray Valley encephalitis virus (MVEV) is a flavivirus that occurs in Australia and New Guinea. While clinical cases are uncommon, MVEV can cause severe encephalitis with high mortality. Sentinel chicken ...
The zoonotic flaviviruses of southern, south-eastern and eastern Asia, and Australasia: the potential for emergent virusesMacKenzie, John; Williams, David (2009)The genus Flaviviridae comprises about 70 members, of which about 30 are found in southern, south-eastern and eastern Asia and Australasia. These include major pathogens such as Japanese encephalitis (JE), West Nile (WN), ...
Selvey, Linda; Speers, D.; Smith, D. (2015)BACKGROUND: Murray Valley encephalitis virus (MVEV) is a mosquito-borne flavivirus that causes encephalitis in some cases of infection. It is endemic in Northern Australia and cases occasionally occur in South Eastern ...