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    Platelet-VWF complexes get the chop

    Access Status
    Open access via publisher
    Authors
    Berndt, Michael
    Andrews, R.
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Berndt, M. and Andrews, R. 2008. Platelet-VWF complexes get the chop. Blood. 111 (2).
    Source Title
    Blood
    DOI
    10.1182/blood-2007-10-116012
    ISSN
    0006-4971
    Faculty
    Faculty of Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/45221
    Collection
    • Curtin Research Publications
    Abstract

    In this issue of Blood, Shim and colleagues define a dual role for platelet glycoprotein (GP)Iba (the major ligand-binding subunit of the GPIb-IX-V complex) in regulating ADAMTS13-mediated cleavage of von Willebrand factor (VWF) under shear: it alleviates an inhibitory effect of the VWFA1 domain on cleavage of the A2 domain, 1 and it allows tensile force to be exerted on the A2 domain through at least 2 platelets binding per VWF multimer via the A1 domain (see figure).

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