Platelet-VWF complexes get the chop
| dc.contributor.author | Berndt, Michael | |
| dc.contributor.author | Andrews, R. | |
| dc.date.accessioned | 2017-01-30T15:19:22Z | |
| dc.date.available | 2017-01-30T15:19:22Z | |
| dc.date.created | 2016-09-12T08:36:24Z | |
| dc.date.issued | 2008 | |
| dc.identifier.citation | Berndt, M. and Andrews, R. 2008. Platelet-VWF complexes get the chop. Blood. 111 (2). | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/45221 | |
| dc.identifier.doi | 10.1182/blood-2007-10-116012 | |
| dc.description.abstract |
In this issue of Blood, Shim and colleagues define a dual role for platelet glycoprotein (GP)Iba (the major ligand-binding subunit of the GPIb-IX-V complex) in regulating ADAMTS13-mediated cleavage of von Willebrand factor (VWF) under shear: it alleviates an inhibitory effect of the VWFA1 domain on cleavage of the A2 domain, 1 and it allows tensile force to be exerted on the A2 domain through at least 2 platelets binding per VWF multimer via the A1 domain (see figure). | |
| dc.publisher | American Society of Hematology | |
| dc.title | Platelet-VWF complexes get the chop | |
| dc.type | Journal Article | |
| dcterms.source.volume | 111 | |
| dcterms.source.number | 2 | |
| dcterms.source.issn | 0006-4971 | |
| dcterms.source.title | Blood | |
| curtin.accessStatus | Open access via publisher | |
| curtin.faculty | Faculty of Health Sciences |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||