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dc.contributor.authorBerndt, Michael
dc.contributor.authorAndrews, R.
dc.date.accessioned2017-01-30T15:19:22Z
dc.date.available2017-01-30T15:19:22Z
dc.date.created2016-09-12T08:36:24Z
dc.date.issued2008
dc.identifier.citationBerndt, M. and Andrews, R. 2008. Platelet-VWF complexes get the chop. Blood. 111 (2).
dc.identifier.urihttp://hdl.handle.net/20.500.11937/45221
dc.identifier.doi10.1182/blood-2007-10-116012
dc.description.abstract

In this issue of Blood, Shim and colleagues define a dual role for platelet glycoprotein (GP)Iba (the major ligand-binding subunit of the GPIb-IX-V complex) in regulating ADAMTS13-mediated cleavage of von Willebrand factor (VWF) under shear: it alleviates an inhibitory effect of the VWFA1 domain on cleavage of the A2 domain, 1 and it allows tensile force to be exerted on the A2 domain through at least 2 platelets binding per VWF multimer via the A1 domain (see figure).

dc.publisherAmerican Society of Hematology
dc.titlePlatelet-VWF complexes get the chop
dc.typeJournal Article
dcterms.source.volume111
dcterms.source.number2
dcterms.source.issn0006-4971
dcterms.source.titleBlood
curtin.accessStatusOpen access via publisher
curtin.facultyFaculty of Health Sciences


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