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    Lipid-laden partially-activated plasmacytoid and CD4-CD8a+ dendritic cells accumulate in tissues in elderly mice

    213170_138826_Gardner_et_al_Immunity_and_Ageing__2_.pdf (1.075Mb)
    Access Status
    Open access
    Authors
    Gardner, Joanne
    Mamotte, Cyril
    McGonigle, T.
    Dye, Danielle
    Jackaman, Connie
    Nelson, Delia
    Date
    2014
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Gardner, J. and Mamotte, C. and McGonigle, T. and Dye, D. and Jackaman, C. and Nelson, D. 2014. Lipid-laden partially-activated plasmacytoid and CD4-CD8a+ dendritic cells accumulate in tissues in elderly mice. Immunity & Ageing. 11: 11.
    Source Title
    Immunity & Ageing
    DOI
    10.1186/1742-4933-11-11
    Additional URLs
    http://www.immunityageing.com/content/11/1/11
    ISSN
    17424933
    School
    School of Biomedical Sciences
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/45376
    Collection
    • Curtin Research Publications
    Abstract

    Background - Aging is associated with a decline in lymphocyte function however, little is known about dendritic cell (DC) subsets and aging. Aging is also associated with increasing circulating lipid levels and intracellular lipid accumulation modulates DC function. Whether age-associated increases in lipid levels influence DC biology is unknown. Thus, the effects of aging on DC subsets were assessed in vivo using young adult and elderly C57BL/6 J mice. Results - Major age-related changes included increased CD11c+ DC numbers in lymph nodes, spleens and livers, but not lungs, and significantly increased proportions of plasmacytoid (pDC) and CD4-CD8α+ DCs in lymph nodes and livers. Other changes included altered pDC activation status (decreased CD40, increased MHC class-I and MHC class-II), increased lipid content in pDCs and CD4-CD8α+ DCs, and increased expression of key mediators of lipid uptake including lipoprotein lipase, scavenger receptors (CD36, CD68 and LRP-1) in most tissues. Conclusions - Aging is associated with organ-specific numerical changes in DC subsets, and DC activation status, and increased lipid content in pDCs and CD4-CD8α+ DCs. Up-regulation of lipoprotein lipase and scavenger receptors by lipid-rich pDCs and CD4-CD8α+ DCs suggests these molecules contribute to DC lipid accumulation in the elderly. Lipid accumulation and modulated activation in pDCs and CD4-CD8α+ DCs may contribute to the declining responses to vaccination and infection with age.

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