Show simple item record

dc.contributor.authorWood, J.
dc.contributor.authorEllery, Paul
dc.contributor.authorMaroney, S.
dc.contributor.authorMast, A.
dc.date.accessioned2017-01-30T15:21:46Z
dc.date.available2017-01-30T15:21:46Z
dc.date.created2015-10-29T04:10:08Z
dc.date.issued2014
dc.identifier.citationWood, J. and Ellery, P. and Maroney, S. and Mast, A. 2014. Biology of tissue factor pathway inhibitor. Blood. 123 (19): pp. 2934-2943.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/45562
dc.identifier.doi10.1182/blood-2013-11-512764
dc.description.abstract

Recent studies of the anticoagulant activities of the tissue factor (TF) pathway inhibitor (TFPI) isoforms, TFPIa and TFPIß, have provided new insight into the biochemical and physiological meagulant activities. An alternative splicing event in the 59 untranslated region allows for translational regulation of TFPIß expression. TFPIa has 3 Kunitz-type inhibitor domains (K1, K2, K3) and a basic C terminus, whereas TFPIß has the K1 and K2 domains attached to a glycosylphosphatidyl inositol-anchored C terminus. TFPIa is the only isoform present in platelets, whereas endothelial cells produce both isoforms, secreting TFPIa and expressing TFPIb on the cell surface. TFPIa and TFPIß inhibit both TF-factor VIIa-dependent factor Xa (FXa) generation and free FXa. ProteinSenhances FXa inhibition by TFPIa. TFPIa produces isoform-specific inhibition of prothrombinase during the initiation of coagulation, an anticoagulant activity that requires an exosite interaction between its basic C terminus and an acidic region in the factor Va B domain. Platelet TFPIa may be optimally localized to dampen initial thrombin generation. Similarly, endothelial TFPIß may be optimally localized to inhibit processes that occur when endothelial TF is present, such as during the inflammatory response. © 2014 by The American Society of Hematology.

dc.publisherAmerican Society of Hematology
dc.titleBiology of tissue factor pathway inhibitor
dc.typeJournal Article
dcterms.source.volume123
dcterms.source.number19
dcterms.source.startPage2934
dcterms.source.endPage2943
dcterms.source.issn0006-4971
dcterms.source.titleBlood
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record