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    Platelet adhesion: A game of catch and release

    Access Status
    Open access via publisher
    Authors
    Andrews, R.
    Berndt, Michael
    Date
    2008
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Andrews, R. and Berndt, M. 2008. Platelet adhesion: A game of catch and release. Journal of Clinical Investigation. 118 (9): pp. 3009-3011.
    Source Title
    Journal of Clinical Investigation
    DOI
    10.1172/JCI36883
    ISSN
    0021-9738
    Faculty
    Faculty of Health Sciences
    URI
    http://hdl.handle.net/20.500.11937/4558
    Collection
    • Curtin Research Publications
    Abstract

    The interaction of circulating platelets with the vessel wall involves a process of cell catch and release, regulating cell rolling, skipping, or firm adhesion and leading to thrombus formation in flowing blood. In this regard, the interaction of platelet glycoprotein Iba (GPIba) with its adhesive ligand, vWF, is activated by shear force and critical for platelet adhesion to the vessel wall. In this issue of the JCI, Yago and colleagues show how gain-of-function mutations in the GPIba-binding vWF A1 domain disrupt intramolecular interactions within WT vWF A1 that regulate binding to GPIba and flow-enhanced platelet rolling and adhesion (see the related article beginning on page 3195). Together, these studies reveal molecular mechanisms regulating GPIba-vWF bond formation and platelet adhesion under shear stress.

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