Platelet adhesion: A game of catch and release
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The interaction of circulating platelets with the vessel wall involves a process of cell catch and release, regulating cell rolling, skipping, or firm adhesion and leading to thrombus formation in flowing blood. In this regard, the interaction of platelet glycoprotein Iba (GPIba) with its adhesive ligand, vWF, is activated by shear force and critical for platelet adhesion to the vessel wall. In this issue of the JCI, Yago and colleagues show how gain-of-function mutations in the GPIba-binding vWF A1 domain disrupt intramolecular interactions within WT vWF A1 that regulate binding to GPIba and flow-enhanced platelet rolling and adhesion (see the related article beginning on page 3195). Together, these studies reveal molecular mechanisms regulating GPIba-vWF bond formation and platelet adhesion under shear stress.
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Molecular cloning and characterization of rhesus monkey platelet glycoprotein Iba, a major ligand-binding subunit of GPIb-IX-V complexQiao, J.; Shen, Y.; Shi, M.; Lu, Y.; Cheng, J.; Chen, Younan (2014)Introduction Through binding to von Willebrand factor (VWF), platelet glycoprotein (GP) Iba, the major ligand-binding subunit of the GPIb-IX-V complex, initiates platelet adhesion and aggregation in response to exposed ...
Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIba.Carrim, N.; Arthur, J.; Hamilton, J.; Gardiner, E.; Andrews, R.; Moran, N.; Berndt, Michael; Metharom, Pat (2015)BACKGROUND: Platelets are essential for maintaining haemostasis and play a key role in the pathogenesis of cardiovascular disease. Upon ligation of platelet receptors through subendothelial matrix proteins, intracellular ...
Shi, M.; Qiao, J.; Shen, Y.; Lu, Y.; Chen, Younan; Cheng, J. (2012)Glycoprotein Ib-IX-V (GPIb-IX-V) is a platelet adhesion receptor complex that initiates platelet aggregation. Glycoprotein Iba (GPIba) is the central component of the GPIb-IX-V complex, anchoring the complex to the ...