Show simple item record

dc.contributor.authorAndrews, R.
dc.contributor.authorBerndt, Michael
dc.date.accessioned2017-01-30T10:40:04Z
dc.date.available2017-01-30T10:40:04Z
dc.date.created2016-09-12T08:36:24Z
dc.date.issued2008
dc.identifier.citationAndrews, R. and Berndt, M. 2008. Platelet adhesion: A game of catch and release. Journal of Clinical Investigation. 118 (9): pp. 3009-3011.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/4558
dc.identifier.doi10.1172/JCI36883
dc.description.abstract

The interaction of circulating platelets with the vessel wall involves a process of cell catch and release, regulating cell rolling, skipping, or firm adhesion and leading to thrombus formation in flowing blood. In this regard, the interaction of platelet glycoprotein Iba (GPIba) with its adhesive ligand, vWF, is activated by shear force and critical for platelet adhesion to the vessel wall. In this issue of the JCI, Yago and colleagues show how gain-of-function mutations in the GPIba-binding vWF A1 domain disrupt intramolecular interactions within WT vWF A1 that regulate binding to GPIba and flow-enhanced platelet rolling and adhesion (see the related article beginning on page 3195). Together, these studies reveal molecular mechanisms regulating GPIba-vWF bond formation and platelet adhesion under shear stress.

dc.publisherAmerican Society for Clinical Investigation
dc.titlePlatelet adhesion: A game of catch and release
dc.typeJournal Article
dcterms.source.volume118
dcterms.source.number9
dcterms.source.startPage3009
dcterms.source.endPage3011
dcterms.source.issn0021-9738
dcterms.source.titleJournal of Clinical Investigation
curtin.accessStatusOpen access via publisher
curtin.facultyFaculty of Health Sciences


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record