Associations between serum cortisol, cardiovascular function and neurological outcome following acute global hypoxia in the newborn piglet
MetadataShow full item record
Perinatal asphyxia is a significant contributor to neonatal brain injury. However, there is significant variability in neurological outcome in neonates after global hypoxiaischemia. The aims of this study were to identify which physiological response/s during global hypoxiaischemia influence the severity of brain injury and to assess their relative importance. Hypoxia/hypercapnia was induced in 20 anaesthetized piglets by reducing the inspired oxygen fraction to 10% and the ventilation rate from 30 to 10 breaths per minute for 45 min. Neurological outcome was assessed using functional markers including cerebral function amplitude (via electroencephalography) and cerebral impedance, and the structural marker microtubule associated protein-2 by immunohistochemistry at 6 h post hypoxia. Significant variability in neurological outcome was observed following the constant hypoxia/hypercapnia insult. There was a high degree of variability in cardiovascular function (mean arterial blood pressure and heart rate) and serum cortisol concentrations in response to hypoxia. More effective maintenance of cardiovascular function and higher serum cortisol concentrations were associated with a better outcome. These two variables were strongly associated with neurological outcome, and together explained 68% of the variation in the severity of neurological outcome. The variability in the cardiovascular and cortisol responses to hypoxia may be a more important determinant of neurological outcome then previously recognized.
Showing items related by title, author, creator and subject.
Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in femalesHarris, T.; Healy, Genevieve; Colditz, P.; Lingwood, B. (2009)The function of the cardiovascular system during hypoxia is an important determinant of neurologic outcome. Oscillations in blood pressure, particularly type-3 waves with a duration of 10 to 160 s, have been shown to occur ...
The role of functional, radiological and self-reported measures in predicting clinical outcome in spondylotic cervical radiculopathyAgarwal, Shabnam (2011)BackgroundCervical radiculopathy (CR) results in significant disability and pain and is commonly treated conservatively with satisfactory clinical outcomes. However, a considerable number of patients require surgery to ...
Exploring different models of stroke unit care and outcome : the Stroke Rehabilitation Outcome (SRO) studyDennis, Diane (2013)Introduction: Stroke is a significant cardiovascular event requiring sub-acute rehabilitation, best provided in a stroke unit (SU). These units include dedicated neurological SUs usually catering only for patients with ...