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    Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in females

    Access Status
    Fulltext not available
    Authors
    Harris, T.
    Healy, Genevieve
    Colditz, P.
    Lingwood, B.
    Date
    2009
    Type
    Journal Article
    
    Metadata
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    Citation
    Harris, T. and Healy, G. and Colditz, P. and Lingwood, B. 2009. Oscillations in cardiovascular function during acute hypoxia in the newborn piglet are associated with less neurological damage and occur more frequently in females. Pediatric Research. 65 (5): pp. 504-508.
    Source Title
    Pediatric Research
    DOI
    10.1203/PDR.0b013e31819d9747
    ISSN
    0031-3998
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/46790
    Collection
    • Curtin Research Publications
    Abstract

    The function of the cardiovascular system during hypoxia is an important determinant of neurologic outcome. Oscillations in blood pressure, particularly type-3 waves with a duration of 10 to 160 s, have been shown to occur in the presence of hypoxia in the neonatal rat. The aim of this study was to determine the characteristics and occurrence of type-3 waves in the neonatal piglet and any relationship to neurologic damage after acute global hypoxia. Hypoxia/hypercarbia was induced in 32 anesthetized piglets by reducing the fraction of inspired oxygen to 0.1 and the ventilation rate from 30 to 10 breaths per minute for 45 min. The degree of neurologic damage was assessed using both physiologic (EEG amplitude and cerebral impedance at 6 h posthypoxia) and structural (microtubule associated protein-2 immunohistochemistry) markers. Type-3 waves in cardiovascular function occurred in 56% of animals. An oscillating pattern was significantly associated with less neurologic damage (p = 0.01) and a lower duration of hypotension during hypoxia (p = 0.02), and occurred more frequently in females (p = 0.024). Copyright © 2009 International Pediatric Research Foundation, Inc.

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