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    Long-term Effects of Pediatric Burns on the Circulatory System.

    Access Status
    Open access via publisher
    Authors
    Duke, J.
    Randall, S.
    Fear, M.
    Boyd, James
    Rea, S.
    Wood, F.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Duke, J. and Randall, S. and Fear, M. and Boyd, J. and Rea, S. and Wood, F. 2015. Long-term Effects of Pediatric Burns on the Circulatory System.. Pediatrics.
    Source Title
    Pediatrics
    DOI
    10.1542/peds.2015-1945
    School
    Centre for Population Health Research
    URI
    http://hdl.handle.net/20.500.11937/46845
    Collection
    • Curtin Research Publications
    Abstract

    BACKGROUND: The systemic responses to burns (in particular, elevated levels of catecholamines and stress hormones) have been shown to have an impact on cardiac function for at least 3 years in children with burns. However, it is not clear if these changes lead to long-term effects on the heart. The aim of this study was to assess whether pediatric burn injury is associated with increased long-term hospital use for circulatory diseases. METHODS: A population-based longitudinal study was undertaken using linked hospital and death data from Western Australia for children younger than 15 years when hospitalized for a first burn injury (n = 10?436) in 1980-2012 and a frequency matched noninjury comparison cohort, randomly selected from Western Australia's birth registrations (n = 40?819). Crude admission rates and cumulative length of stay for circulatory diseases were calculated. Negative binomial and Cox proportional hazards regression modeling were used to generate incidence rate ratios and hazard ratios, respectively. RESULTS: After adjustment for demographic factors and preexisting health status, the burn cohort had 1.33 (incidence rate ratio) times (95% confidence interval [CI]: 1.08-1.64) as many circulatory system hospitalizations, 2.26 times the number of days in hospital with a diagnosis of a circulatory disease (2.26, 95% CI: 1.06-4.81), and were at a higher risk of incident admissions (hazard ratio 1.22, 95% CI: 1.03-1.46), compared with the uninjured cohort. CONCLUSIONS: Children who sustain burn injury experience elevated hospital admission rates and increased length of hospital stay for diseases of the circulatory system for a prolonged period of time after burn discharge.

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    • Understanding the long-term impacts of burn on the cardiovascular system
      Duke, J.; Randall, Sean; Fear, M.; Boyd, James; Rea, S.; Wood, F. (2015)
      Background: Whilest the most obvious impact of burn is on the skin, systemic responses also occur after burn that lead to wide-spread changes to the body, including the heart. The aim of this study was to assess if burn ...
    • A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people
      Duke, J.; Randall, Sean; Boyd, J.; Fear, M.; Rea, S.; Wood, F. (2018)
      Background: Injury triggers a range of systemic effects including inflammation and immune responses. This study aimed to compare infectious disease admissions after burn and other types of injury using linked hospital ...
    • Burns and long-term infectious disease morbidity: A population-based study
      Duke, J.; Randall, Sean; Wood, F.; Boyd, James H.; Fear, M. (2016)
      Background: There is a growing volume of data that indicates that serious injury suppresses immune function, predisposing individuals to infectious complications. With recent evidence showing long-term immune dysfunction ...
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