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    Ankylosing spondylitis patients commencing biologic therapy have high baseline levels of comorbidity: A report from the Australian Rheumatology Association database

    215823_215823.pdf (1.216Mb)
    Access Status
    Open access
    Authors
    Oldroyd, J.
    Schachna, L.
    Buchbinder, R.
    Staples, M.
    Murphy, B.
    Bond, M.
    Briggs, Andrew
    Lassere, M.
    March, L.
    Date
    2009
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Oldroyd, J. and Schachna, L. and Buchbinder, R. and Staples, M. and Murphy, B. and Bond, M. and Briggs, A. et al. 2009. Ankylosing spondylitis patients commencing biologic therapy have high baseline levels of comorbidity: A report from the Australian Rheumatology Association database. International Journal of Rheumatology. 2009: Article ID: 268569.
    Source Title
    International Journal of Rheumatology
    DOI
    10.1155/2009/268569
    ISSN
    1687-9260
    School
    School of Physiotherapy and Exercise Science
    Remarks

    This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons License http://creativecommons.org/licenses/by/3.0/ Please refer to the licence to obtain terms for any further reuse or distribution of this work.

    URI
    http://hdl.handle.net/20.500.11937/47395
    Collection
    • Curtin Research Publications
    Abstract

    Aims. To compare the baseline characteristics of a population-based cohort of patients with ankylosing spondylitis (AS) commencing biological therapy to the reported characteristics of bDMARD randomised controlled trials (RCTs) participants. Methods. Descriptive analysis of AS participants in the Australian Rheumatology Association Database (ARAD) who were commencing bDMARD therapy. Results. Up to December 2008, 389 patients with AS were enrolled in ARAD. 354 (91.0%) had taken bDMARDs at some time, and 198 (55.9%) completed their entry questionnaire prior to or within 6 months of commencing bDMARDs. 131 (66.1%) had at least one comorbid condition, and 24 (6.8%) had a previous malignancy (15 nonmelanoma skin, 4 melanoma, 2 prostate, 1 breast, cervix, and bowel). Compared with RCT participants, ARAD participants were older, had longer disease duration and higher baseline disease activity. Conclusions. AS patients commencing bDMARDs in routine care are significantly different to RCT participants and have significant baseline comorbidities.

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