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    Effect of the velopharynx on intraluminal pressures in reconstructed pharynges derived from individuals with and without sleep apnea

    194729_194729.pdf (1.560Mb)
    Access Status
    Open access
    Authors
    Cisonni, Julien
    Lucey, Anthony
    Walsh, J.
    King, Andrew
    Elliott, Novak
    Sampson, D.
    Eastwood, P.
    Hillman, D.
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Cisonni, Julien and Lucey, Anthony D. and Walsh, Jennifer H. and King, Andrew J.C. and Elliott, Novak S.J. and Sampson, David D. and Eastwood, Peter R. and Hillman, David R. 2013. Effect of the velopharynx on intraluminal pressures in reconstructed pharynges derived from individuals with and without sleep apnea. Journal of Biomechanics. 46 (14): pp. 2504-2512.
    Source Title
    Journal of Biomechanics
    DOI
    10.1016/j.jbiomech.2013.07.007
    ISSN
    0021-9290
    Remarks

    NOTICE: This is the author’s version of a work that was accepted for publication in Journal of Biomechanics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Biomechanics, Vol. 46, Issue 14 (2013). doi: 10.1016/j.jbiomech.2013.07.007

    URI
    http://hdl.handle.net/20.500.11937/47942
    Collection
    • Curtin Research Publications
    Abstract

    The most collapsible part of the upper airway in the majority of individuals is the velopharynx which is the segment positioned behind the soft palate. As such it is an important morphological region for consideration in elucidating the pathogenesis of obstructive sleep apnea (OSA). This study compared steady flow properties during inspiration in the pharynges of nine male subjects with OSA and nine body-mass index (BMI)- and age-matched control male subjects without OSA. The k–ωωSST turbulence model was used to simulate the flow field in subject-specific pharyngeal geometric models reconstructed from anatomical optical coherence tomography (aOCT) data. While analysis of the geometry of reconstructed pharynges revealed narrowing at velopharyngeal level in subjects with OSA, it was not possible to clearly distinguish them from subjects without OSA on the basis of pharyngeal size and shape alone. By contrast, flow simulations demonstrated that pressure fields within the narrowed airway segments were sensitive to small differences in geometry and could lead to significantly different intraluminal pressure characteristics between subjects. The ratio between velopharyngeal and total pharyngeal pressure drops emerged as a relevant flow-based criterion by which subjects with OSA could be differentiated from those without.

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