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dc.contributor.authorCisonni, Julien
dc.contributor.authorLucey, Anthony
dc.contributor.authorWalsh, J.
dc.contributor.authorKing, Andrew
dc.contributor.authorElliott, Novak
dc.contributor.authorSampson, D.
dc.contributor.authorEastwood, P.
dc.contributor.authorHillman, D.
dc.date.accessioned2017-01-30T15:36:39Z
dc.date.available2017-01-30T15:36:39Z
dc.date.created2014-02-03T20:02:09Z
dc.date.issued2013
dc.identifier.citationCisonni, Julien and Lucey, Anthony D. and Walsh, Jennifer H. and King, Andrew J.C. and Elliott, Novak S.J. and Sampson, David D. and Eastwood, Peter R. and Hillman, David R. 2013. Effect of the velopharynx on intraluminal pressures in reconstructed pharynges derived from individuals with and without sleep apnea. Journal of Biomechanics. 46 (14): pp. 2504-2512.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/47942
dc.identifier.doi10.1016/j.jbiomech.2013.07.007
dc.description.abstract

The most collapsible part of the upper airway in the majority of individuals is the velopharynx which is the segment positioned behind the soft palate. As such it is an important morphological region for consideration in elucidating the pathogenesis of obstructive sleep apnea (OSA). This study compared steady flow properties during inspiration in the pharynges of nine male subjects with OSA and nine body-mass index (BMI)- and age-matched control male subjects without OSA. The k–ωωSST turbulence model was used to simulate the flow field in subject-specific pharyngeal geometric models reconstructed from anatomical optical coherence tomography (aOCT) data. While analysis of the geometry of reconstructed pharynges revealed narrowing at velopharyngeal level in subjects with OSA, it was not possible to clearly distinguish them from subjects without OSA on the basis of pharyngeal size and shape alone. By contrast, flow simulations demonstrated that pressure fields within the narrowed airway segments were sensitive to small differences in geometry and could lead to significantly different intraluminal pressure characteristics between subjects. The ratio between velopharyngeal and total pharyngeal pressure drops emerged as a relevant flow-based criterion by which subjects with OSA could be differentiated from those without.

dc.publisherElsevier
dc.subjectVelopharynx
dc.subjectPharyngeal wall pressure
dc.subjectObstructive sleep apnea
dc.subjectAirway resistance
dc.subjectCFD
dc.titleEffect of the velopharynx on intraluminal pressures in reconstructed pharynges derived from individuals with and without sleep apnea
dc.typeJournal Article
dcterms.source.volume46
dcterms.source.number14
dcterms.source.startPage2504
dcterms.source.endPage2512
dcterms.source.issn0021-9290
dcterms.source.titleJournal of Biomechanics
curtin.note

NOTICE: This is the author’s version of a work that was accepted for publication in Journal of Biomechanics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Biomechanics, Vol. 46, Issue 14 (2013). doi: 10.1016/j.jbiomech.2013.07.007

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curtin.accessStatusOpen access


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