The usefulness of fungicide mixtures and alternation for delaying the selection for resistance in populations of mycosphaerella graminicola on winter wheat: A modeling analysis
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A fungicide resistance model (reported and tested previously) was amended to describe the development of resistance in Mycosphaerella graminicola populations in winter wheat (Triticum aestivum) crops in two sets of fields, connected by spore dispersal. The model was used to evaluate the usefulness of concurrent, alternating, or mixture use of two high-resistance-risk fungicides as resistance management strategies. We determined the effect on the usefulness of each strategy of (i) fitness costs of resistance, (ii) partial resistance to fungicides, (iii) differences in the dose-response curves and decay rates between fungicides, and (iv) different frequencies of the double-resistant strain at the start of a treatment strategy. Parameter values for the quinine outside inhibitor pyraclostrobin were used to represent two fungicides with differing modes of action. The effectiveness of each strategy was quantified as the maximum number of growing seasons that disease was effectively controlled in both sets of fields. For all scenarios, the maximum effective lives achieved by the use of the strategies were in the order mixtures ≥ alternation ≥ concurrent use. Mixtures were of particular benefit where the pathogen strain resistant to both modes of action incurred a fitness penalty or was present at a low initial frequency.
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Van Den Bosch, F.; Paveley, N.; Van Den Berg, F.; Hobbelen, P.; Oliver, Richard (2014)We have reviewed the experimental and modeling evidence on the use of mixtures of fungicides of differing modes of action as a resistance management tactic. The evidence supports the following conclusions. 1. Adding a ...
Oliver, Richard (2016)Evolved resistance to fungicides is a critical issue for global food security. Resistance has emerged rapidly in some cases, and some so it is vital that the effective life of actives is prolonged as much as practicable. ...
van den Bosch, F.; Paveley, N.; Fraaije, B.; van den Berg, F.; Oliver, Richard (2015)The control of fungal plant pathogens has been characterised by repeated cycles of introduction of new fungicides and for many of them a subsequent loss of efficacy due to the emergence and selection of resistant pathogen ...